Liver injury at admission and outcomes in patients with COVID-19 disease: a prospective cohort study.

Autor:	Poudel S; Department of Gastroenterology., Mishra A; Kathmandu Medical College Teaching Hospital., Poudel SC; Department of Gastroenterology., Baskota A; Kathmandu Medical College Teaching Hospital., Bhattarai M; Department of Internal Medicine, Kathmandu Medical College Teaching Hospital., Aryal A; Department of Internal Medicine, Kathmandu Medical College Teaching Hospital., Kunwar A; Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Apr 17; Vol. 85 (5), pp. 1534-1538. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000000645
Abstrakt:	The liver is one of the common extrapulmonary organs involved in the coronavirus disease 2019 (COVID-19) infection. We aimed to find the prevalence of liver injury at hospital admission and its effects on outcomes. Methods: This is a single-center prospective observational study. All consecutive patients with COVID-19 admitted during the months of May to August 2021 were included in the study. Liver injury was defined as at least 2 times elevation of aspartate transaminase, alanine transaminase, alkaline phosphatase, and bilirubin above the upper limits on normal. The predictive efficacy of liver injury was measured as its effects on outcome variables, that is duration of hospital stay, requirement of ICU admission, mechanical ventilation, and mortality. Presence of liver injury compared with existing biomarkers markers of severe disease, that is lactate dehydrogenase, D-dimer, and C-reactive protein. Results: A total of 245 consecutive adult patients with COVID-19 infection were included in the study. Liver injury was present in 102 (41.63%) of patients. There was a significant association between the presence of liver injury and duration of hospital stay (10.74 vs. 8.9 days; P =0.013), the requirement of ICU admission (12.7 vs. 10.2%; P =0.018), mechanical ventilation (10.6% vs. 6.5%; P =0.003), and mortality (13.1% vs. 6.1%; P <0.001). Liver injury was significantly associated ( P <0.001) with the corresponding elevation of serum biomarkers of severity. Conclusion: The presence of liver injury in patients with COVID-19 infection at the time of hospital admission is the independent predictor of poor outcomes and can also be used as the marker of disease severity. Competing Interests: None of the authors have any conflicts of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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