Lymphatic differentiation and microvascular proliferation in benign vascular lesions of skin and soft tissue: Diagnostic features following the International Society for The Study of Vascular Anomalies Classification-A retrospective study.

Autor:	Utami AM; Department of Pathology, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.; Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia., Lokhorst MM; Department of Plastic Surgery, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Meijer-Jorna LB; Symbiant Pathology, Noord-west Ziekenhuis (NWZ)- Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands., Kruijt MA; Department of Pathology, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Horbach SER; Department of Plastic Surgery, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., de Boer OJ; Department of Pathology, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., van der Horst CMAM; Department of Plastic Surgery, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., van der Wal AC; Department of Pathology, Amsterdam University Medical Center-Location Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	JAAD international [JAAD Int] 2023 Apr 06; Vol. 12, pp. 15-23. Date of Electronic Publication: 2023 Apr 06 (Print Publication: 2023).
DOI:	10.1016/j.jdin.2023.03.009
Abstrakt:	Background: Discrepancies have been noted between the clinical and histologic diagnosis of vascular malformations. Objective: To evaluate the effectiveness of the International Society for Study of Vascular Anomalies (ISSVA) classification in diagnosing benign vascular anomalies based on clinical and (immuno) histologic parameters, focusing on lymphatic differentiation and vascular proliferation. Method: A retrospective study of 121 consecutive patients with benign skin and soft-tissue vascular anomalies located in the head and neck region (pyogenic granulomas and angioma senilis were excluded) by applying multiplex immunohistochemistry staining for lymph vessels (D2-40), endothelial blood vessels, and proliferating cells (Ki67). Clinical and histologic diagnosis was revised after the ISSVA classification. Results: Initially, 64 lesions were diagnosed as tumors and 57 as malformations. Revision diagnosis following the ISSVA classification revealed 27 tumors, 90 malformations (22.2% lymphatic), and 4 non-ISSVA. Immunostaining showed lymphatic differentiation in 24 (19.8%) of 121 cases, of which 20 were malformations. Proliferative activity (Ki67+) was found in 41 (33.8%) of 121 cases, of which 8 were arteriovenous malformations. Limitation: Quality and size of materials (biopsies vs resections) and clinical information. Conclusion: The diagnostic accuracy of combined histologic and clinical approaches for identifying vascular anomalies following the ISSVA classification can be substantially enhanced by incorporating additional immunostaining techniques to evaluate lymphatic differentiation and proliferative activity, particularly in identifying the occurrence of vascular malformations. Competing Interests: None disclosed. (© 2023 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.)
Databáze:	MEDLINE
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