Safety of intracameral application of moxifloxacin and dexamethasone (Vigadexa®) after phacoemulsification surgery.

Autor: Galvis V; Centro Oftalmológico Virgilio Galvis, Calle 158 20-95, Consultorio 301, Torre C, Cañaveral, Floridablanca, Santander, Colombia.; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia., Prada AM; Centro Oftalmológico Virgilio Galvis, Calle 158 20-95, Consultorio 301, Torre C, Cañaveral, Floridablanca, Santander, Colombia.; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia., Tello A; Centro Oftalmológico Virgilio Galvis, Calle 158 20-95, Consultorio 301, Torre C, Cañaveral, Floridablanca, Santander, Colombia. alejandrotello@gmail.com.; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia. alejandrotello@gmail.com.; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia. alejandrotello@gmail.com.; Universidad Industrial de Santander (UIS), Bucaramanga, Colombia. alejandrotello@gmail.com., Parra MM; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.; Universidad Industrial de Santander (UIS), Bucaramanga, Colombia., Camacho PA; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia., Polit MP; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.; Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2023 Nov; Vol. 261 (11), pp. 3215-3221. Date of Electronic Publication: 2023 May 25.
DOI: 10.1007/s00417-023-06095-0
Abstrakt: Background: Intracameral antibiotics, such as moxifloxacin and cefuroxime, are safe to corneal endothelial cells and effective prophylaxis of endophthalmitis after cataract surgery. Corneal endothelial cells decrease in density after cataract surgery. Any substance used in the anterior chamber may affect corneal endothelial cells and lead to a greater decrease in density. This study wants to determine the percentage of endothelial cell loss after cataract extraction by phacoemulsification with off-label intracameral injection of moxifloxacin and dexamethasone (Vigadexa®).
Methods: An observational retrospective study was performed. The clinical records of patients undergoing cataract surgery by phacoemulsification plus intracameral injection of Vigadexa® were analyzed. Endothelial cell loss (ECL) was calculated using preoperative and postoperative endothelial cell density. The relation of endothelial cell loss with cataract grade using LOCS III classification, total surgery time, total ultrasound time, total longitudinal power time, total torsional amplitude time, total aspiration time, estimated fluid usage, and cumulative dissipated energy (CDE) was studied using univariate linear regression analysis and logistic regression analysis.
Results: The median loss of corneal endothelial cells was 4.6%, interquartile range 0 to 10.4%. Nuclear color and CDE were associated with increased ECL. ECL>10% was associated with age and total ultrasound time in seconds.
Conclusions: The endothelial cell loss after the intracameral use of Vigadexa® at the end of cataract surgery was similar to the reported in other studies of cataract surgery without the use of intracameral prophylaxis for postoperative endophthalmitis (POE). This study confirmed the association of CDE and nuclear opalescence grade with postoperative corneal endothelial cell loss.
(© 2023. The Author(s).)
Databáze: MEDLINE
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