Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial.

Autor:	Qian J; 1Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.; 2Division of Sleep Medicine, Harvard Medical School, Boston, MA., Xiao Q; 3Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Walkup MP; 4School of Medicine, Wake Forest University, Winston-Salem, NC., Coday M; 5Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN., Erickson ML; 6Translational Research Institute, AdventHealth, Orlando, FL., Unick J; 7Weight Control and Diabetes Research Center, Miriam Hospital, Providence, RI., Jakicic JM; 8Division of Physical Activity and Weight Management, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS., Hu K; 1Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.; 2Division of Sleep Medicine, Harvard Medical School, Boston, MA., Scheer FAJL; 1Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.; 2Division of Sleep Medicine, Harvard Medical School, Boston, MA., Middelbeek RJW; 9Joslin Diabetes Center, Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2023 Jul 01; Vol. 46 (7), pp. 1417-1424.
DOI:	10.2337/dc22-2413
Abstrakt:	Objective: We aimed to determine the association of the time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control across 4 years in adults with overweight/obesity and type 2 diabetes. Research Design and Methods: Among 2,416 participants (57% women; mean age, 59 years) with 7-day waist-worn accelerometry recording at year 1 or 4, we assigned bMVPA timing groups based on the participants' temporal distribution of bMVPA at year 1 and recategorized them at year 4. The time-varying exposure of bMVPA (≥10-min bout) timing was defined as ≥50% of bMVPA occurring during the same time period (morning, midday, afternoon, or evening), <50% of bMVPA in any time period (mixed), and ≤1 day with bMVPA per week (inactive). Results: HbA1c reduction at year 1 varied among bMVPA timing groups (P = 0.02), independent of weekly bMVPA volume and intensity. The afternoon group had the greatest HbA1c reduction versus inactive (-0.22% [95%CI -0.39%, -0.06%]), the magnitude of which was 30-50% larger than the other groups. The odds of discontinuation versus maintaining or initiating glucose-lowering medications at year 1 differed by bMVPA timing (P = 0.04). The afternoon group had the highest odds (odds ratio 2.13 [95% CI 1.29, 3.52]). For all the year-4 bMVPA timing groups, there were no significant changes in HbA1c between year 1 and 4. Conclusions: bMVPA performed in the afternoon is associated with improvements in glycemic control in adults with diabetes, especially within the initial 12 months of an intervention. Experimental studies are needed to examine causality. (© 2023 by the American Diabetes Association.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu