Views of parents of children with Down syndrome on Alzheimer's disease vaccination.

Autor:	Batbold S; Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA., Cummings G; Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA., Riggan KA; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA., Michie M; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Allyse M; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	Journal of intellectual disabilities : JOID [J Intellect Disabil] 2024 Sep; Vol. 28 (3), pp. 759-772. Date of Electronic Publication: 2023 May 24.
DOI:	10.1177/17446295231177787
Abstrakt:	Individuals with Down syndrome (DS) experience increased risk of Alzheimer's disease (AD). Recent studies suggest that a vaccine against AD may be forthcoming. Parental buy-in is critical to the success of any intervention in this population, as adults with DS often rely on familial support. This study aims to characterize parents' perceptions of a hypothetical vaccine to prevent AD in individuals with DS. A mixed-methods, anonymous survey was distributed via social media. Participants were asked about their experiences with DS and reactions to proposed interventions. Open-ended responses were thematically analyzed using NVivo 12. Of 1,093 surveys initiated, 532 were completed. Of the parents sampled (N = 532), a small majority (54.3%), supported the proposed AD vaccine. All expressed the need for extensive pre-enrollment education and minimal risk. For many, limited research and long-term sequelae were concerns. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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