Structural basis of amine odorant perception by a mammal olfactory receptor.
Autor: | Guo L; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China.; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Cheng J; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China.; Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China., Lian S; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China., Liu Q; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Lu Y; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Zheng Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China., Zhu K; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China., Zhang M; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China., Kong Y; Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Center for Brain Science, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang C; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Rong N; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Zhuang Y; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Fang G; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Jiang J; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Zhang T; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Han X; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China.; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Liu Z; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China., Xia M; Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China., Liu S; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China., Zhang L; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an, China., Liberles SD; Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Yu X; Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan, China., Xu Y; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China. xuyunfei1988@126.com., Yang F; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China. yangfan1357@163.com.; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China. yangfan1357@163.com., Li Q; Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liqian@shsmu.edu.cn.; Center for Brain Science, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. liqian@shsmu.edu.cn.; Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liqian@shsmu.edu.cn.; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, China. liqian@shsmu.edu.cn., Sun JP; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, China. sunjinpeng@sdu.edu.cn.; Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China. sunjinpeng@sdu.edu.cn.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. sunjinpeng@sdu.edu.cn. |
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Jazyk: | angličtina |
Zdroj: | Nature [Nature] 2023 Jun; Vol. 618 (7963), pp. 193-200. Date of Electronic Publication: 2023 May 24. |
DOI: | 10.1038/s41586-023-06106-4 |
Abstrakt: | Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-coupled receptor families, the odorant receptors and the trace amine-associated receptors 1,2 (TAARs). TAARs emerged following the divergence of jawed and jawless fish, and comprise a large monophyletic family of receptors that recognize volatile amine odorants to elicit both intraspecific and interspecific innate behaviours such as attraction and aversion 3-5 . Here we report cryo-electron microscopy structures of mouse TAAR9 (mTAAR9) and mTAAR9-G (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.) |
Databáze: | MEDLINE |
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