A median fin derived from the lateral plate mesoderm and the origin of paired fins.

Autor: Tzung KW; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Lalonde RL; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Prummel KD; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Mahabaleshwar H; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Moran HR; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Stundl J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic., Cass AN; Biology Department, Wesleyan University, Middletown, CT, USA., Le Y; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore., Lea R; Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Dorey K; Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Tomecka MJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Zhang C; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Brombacher EC; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., White WT; CSIRO National Research Collections Australia, Australia National Fish Collection, Hobart, Tasmania, Australia., Roehl HH; School of Biosciences, University of Sheffield, Sheffield, UK., Tulenko FJ; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia., Winkler C; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore., Currie PD; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.; EMBL Australia, Victorian Node, Monash University, Clayton, Victoria, Australia., Amaya E; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Davis MC; Department of Physical and Biological Sciences, Western New England University, Springfield, MA, USA., Bronner ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Mosimann C; Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. christian.mosimann@cuanschutz.edu.; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. christian.mosimann@cuanschutz.edu., Carney TJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore. tcarney@ntu.edu.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. tcarney@ntu.edu.sg.
Jazyk: angličtina
Zdroj: Nature [Nature] 2023 Jun; Vol. 618 (7965), pp. 543-549. Date of Electronic Publication: 2023 May 24.
DOI: 10.1038/s41586-023-06100-w
Abstrakt: The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins invokes derivation from unpaired median fins via a pair of lateral fin folds located between pectoral and pelvic fin territories 1 . Whilst unpaired and paired fins exhibit similar structural and molecular characteristics, no definitive evidence exists for paired lateral fin folds in larvae or adults of any extant or extinct species. As unpaired fin core components are regarded as exclusively derived from paraxial mesoderm, any transition presumes both co-option of a fin developmental programme to the LPM and bilateral duplication 2 . Here, we identify that the larval zebrafish unpaired pre-anal fin fold (PAFF) is derived from the LPM and thus may represent a developmental intermediate between median and paired fins. We trace the contribution of LPM to the PAFF in both cyclostomes and gnathostomes, supporting the notion that this is an ancient trait of vertebrates. Finally, we observe that the PAFF can be bifurcated by increasing bone morphogenetic protein signalling, generating LPM-derived paired fin folds. Our work provides evidence that lateral fin folds may have existed as embryonic anlage for elaboration to paired fins.
(© 2023. The Author(s).)
Databáze: MEDLINE
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