Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis.

Autor:	Abay-Nørgaard S; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark noerrebro@hotmail.com., Tapia MC; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Zeijdner M; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Kim JH; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Won KJ; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Porse B; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Salcini AE; Biotech Research and Innovation Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark lisa.salcini@bric.ku.dk.
Jazyk:	angličtina
Zdroj:	Life science alliance [Life Sci Alliance] 2023 May 24; Vol. 6 (8). Date of Electronic Publication: 2023 May 24 (Print Publication: 2023).
DOI:	10.26508/lsa.202301970
Abstrakt:	Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis. (© 2023 Abay-Nørgaard et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu