Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults.

Autor:	Broatch JR; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia james.broatch@vu.edu.au., Zarekookandeh N; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia., Glarin R; Melbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Radiology, The Royal Melbourne Hospital, Parkville, Victoria, Australia., Strik M; Melbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia., Johnston LA; Melbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia., Moffat BA; Melbourne Brain Centre Imaging Unit, Department of Radiology, The University of Melbourne, Melbourne, Victoria, Australia., Bird LJ; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia., Gunningham K; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia., Churilov L; Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia., Johns HT; Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.; Australian Stroke Alliance, Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia., Askew CD; Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Nambour, Queensland, Australia.; School of Health, University of the Sunshine Coast, Maroochydore, Queensland, Australia., Levinger I; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.; The Australian Institute of Musculoskeletal Sciences, Melbourne, Victoria, Australia., O'Riordan SF; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia., Bishop DJ; Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia., Brodtmann A; Cognitive Health Initiative, Central Clinical School, Monash University, Clayton, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 May 24; Vol. 13 (5), pp. e069413. Date of Electronic Publication: 2023 May 24.
DOI:	10.1136/bmjopen-2022-069413
Abstrakt:	Introduction: Regular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the association between greater cardiorespiratory fitness and larger brain volume, superior cognitive performance and lower dementia risk. However, the optimal aerobic exercise dose, namely the intensity and mode of delivery, to improve brain health and lower dementia risk has received less attention. We aim to determine the effect of different doses of aerobic exercise training on markers of brain health in sedentary middle-aged adults, hypothesising that high-intensity interval training (HIIT) will be more beneficial than moderate-intensity continuous training (MICT). Methods and Analysis: In this two-group parallel, open-label blinded endpoint randomised trial, 70 sedentary middle-aged (45-65 years) adults will be randomly allocated to one of two 12-week aerobic exercise training interventions matched for total exercise training volume: (1) MICT (n=35) or HIIT (n=35). Participants will perform ~50 min exercise training sessions, 3 days per week, for 12 weeks. The primary outcome will be measured as between-group difference in cardiorespiratory fitness (peak oxygen uptake) change from baseline to the end of training. Secondary outcomes include between-group differences in cognitive function and ultra-high field MRI (7T) measured markers of brain health (brain blood flow, cerebrovascular function, brain volume, white matter microstructural integrity and resting state functional brain activity) changes from baseline to the end of training. Ethics and Dissemination: The Victoria University Human Research Ethics Committee (VUHREC) has approved this study (HRE20178), and all protocol modifications will be communicated to the relevant parties (eg, VUHREC, trial registry). Findings from this study will be disseminated via peer-review publications, conference presentations, clinical communications and both mainstream and social media. Trial Registration Number: ANZCTR12621000144819. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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