Clinical characteristics of SARS-CoV-2 vaccine-related acute appendicitis.

Autor:	Quint E; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel) elchananq@gmail.com., Kukeev I; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Hazan I; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Grupel D; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Dukhno O; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Osyntsov A; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Sebbag G; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Guetta O; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel)., Czeiger D; Department of General Surgery B, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel (Quint, Kukeev, Dukhno, Osyntsov, Sebbag, Guetta, Czeiger); Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Hazan); Internal Medicine B, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel (Grupel).
Jazyk:	angličtina
Zdroj:	Canadian journal of surgery. Journal canadien de chirurgie [Can J Surg] 2023 May 24; Vol. 66 (3), pp. E304-E309. Date of Electronic Publication: 2023 May 24 (Print Publication: 2023).
DOI:	10.1503/cjs.009322
Abstrakt:	Background: In a large nationwide mass vaccination setting, the SARS-CoV-2 vaccine was recently linked to myocarditis, lymphadenopathy, herpes zoster infection and appendicitis. We aimed to examine the characteristics and management of SARS-CoV-2 vaccine-related acute appendicitis. Methods: We performed a retrospective cohort study in a large tertiary medical centre in Israel. All patients presenting with acute appendicitis within 21 days of receiving their SARS-CoV-2 vaccination (PCVAA group) were compared with patients who presented with acute appendicitis not related to the vaccination (N-PCVAA group). Results: We reviewed the records of 421 patients with acute appendicitis from December 2020 to September 2021; 38 (9%) patients presented with acute appendicitis within 21 days of receiving their SARS-CoV-2 vaccination. Patients in the PCVAA group were older than those in the N-PCVAA group (mean 41 ± 19 yr v. 33 ± 15 yr, respectively, p = 0.008), with male predominance. More patients were managed nonsurgically during the pandemic than before the pandemic (24% v. 18%, p = 0.03). Conclusion: With the exception of older age, the clinical characteristics of patients presenting with acute appendicitis within 21 days of receiving the SARS-CoV-2 vaccination did not differ from those of patients who presented with acute appendicitis not related to the vaccination. This finding suggests that vaccine-related acute appendicitis is similar to "classic" acute appendicitis. Competing Interests: Competing interests: None declared. (© 2023 CMA Impact Inc. or its licensors.)
Databáze:	MEDLINE
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