Daphnane-type diterpenoids from Stellera chamaejasme L. and their inhibitory activity against hepatocellular carcinoma cells.

Autor: Cheng ZY; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, 030000, People's Republic of China., Ren JX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Xue XB; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Wang M; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Yu XQ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Lin B; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Yao GD; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Song SJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Huang XX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, People's Republic of China; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: xiaoxiao270@163.com.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2023 Aug; Vol. 212, pp. 113725. Date of Electronic Publication: 2023 May 22.
DOI: 10.1016/j.phytochem.2023.113725
Abstrakt: Daphnane-type diterpenoids, which are scarce in nature, exhibit potent growth-inhibitory activities against various cancer cells. To identify more daphnane-type diterpenoids, the phytochemical components in the root extracts of Stellera chamaejasme L. were analysed in this study using the Global Natural Products Social platform and the MolNetEnhancer tool. Three undescribed 1α-alkyldaphnane-type diterpenoids (1-3; named stelleradaphnanes A-C) and 15 known analogues were isolated and characterised. The structures of these compounds were determined using ultraviolet and nuclear magnetic resonance spectroscopy. The stereo configurations of the compounds were determined using electronic circular dichroism. Next, the growth-inhibitory activities of isolated compounds against HepG2 and Hep3B cells were examined. Compound 3 exhibited potent growth-inhibitory activities against HepG2 and Hep3B cells with half-maximal inhibitory concentration values of 9.73 and 15.97 μM, respectively. Morphological and staining analyses suggested that compound 3 induced apoptosis in HepG2 and Hep3B cells.
Competing Interests: Declaration of competing interest No declaration of interest statement exists in the submission of this manuscript.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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