C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis.

Autor:	Atas DB; Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey., Sahin GK; Ankara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey., Şengül Ş; Ankara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey., Kaya B; Çukurova University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Adana, Turkey., Paydaş S; Çukurova University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Adana, Turkey., Alibaz-Oner F; Marmara University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey., Direskeneli H; Marmara University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey., Tuglular S; Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey., Asicioglu E; Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Mediterranean journal of rheumatology [Mediterr J Rheumatol] 2023 Mar 31; Vol. 34 (1), pp. 71-77. Date of Electronic Publication: 2023 Mar 31 (Print Publication: 2023).
DOI:	10.31138/mjr.34.1.71
Abstrakt:	Objective/aim: C-reactive protein to albumin ratio (CAR) has recently been recognized as an independent prognostic marker for vasculitides. This study aims to investigate CAR and its relationship with disease activity and damage in prevalent ANCA associated vasculitis (AAV) patients. Methods: Fifty-one patients with AAV and 42 age-sex-matched healthy controls were enrolled in this cross-sectional study. Birmingham vasculitis score (BVAS) was used to assess vasculitis activity and vasculitis damage index (VDI) to provide information on disease damage. Results: The median (25 th -75 th ) age of the patients were 55 (48-61) years. CAR was significantly higher in AAV patients than controls (1.9±2.7 vs 0.7±0.4; p=0.006). The 75 th percentile of BVAS was defined as high BVAS (BVAS≥5) and ROC curve analysis showed that CAR≥0.98 predicted BVAS≥5 with 70.0% sensitivity and 68.0% specificity (AUC:0.660, CI: 0.482-0.837, p=0.049). When patients with CAR≥0.98 were compared to those without, BVAS [5.0 (3.5-8.0) vs. 2.0 (0-3.25), p<0.001], BVAS≥5 [16 (64.0%) vs 4 (15.4%) patients, p:0.001], VDI [4.0 (2.0-4.0) vs. 2.0 (1.0-3.0), p=0.006], and CAR [1.32 (1.07-3.78) vs. 0.75 (0.60-0.83), p<0.001] were higher whereas albumin [3.8 (3.1-4.3) vs. 4.1 (3.9-4.4) g/dL, p=0.025] and haemoglobin [12.1 (10.4-13.4) vs. 13.0 (12.5-14.2) g/dL, p=0.008] were lower. Multivariate analysis revealed that BVAS [OR(95% CI):1.313 (1.003-1.719), p=0.047] was an independent factor associated with CAR≥0.98 in patients with AAV. Furthermore, correlation analysis showed that CAR significantly correlated with BVAS (r: 0.466, p=0.001). Conclusion: In this study, we observed that CAR was significantly associated with disease activity in AAV patients and can be used to monitor disease activity. Competing Interests: The authors declare that there is no conflict of interest. (© 2023 The Mediterranean Journal of Rheumatology (MJR).)
Databáze:	MEDLINE
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