Effects of NO 3 - , Cl - , and CH 3 COO - anions and diethylene glycol on the morphological, structural, antidiabetic, and cell viability properties of CeO 2 nanoparticles.

Autor:	Matussin SN; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link Gadong BE 1410 Brunei Darussalam mmansoobkhan@yahoo.com mansoob.khan@ubd.edu.bn., Khan F; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University Busan 48513 Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University Busan 48513 Republic of Korea., Chandika P; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University Busan 48513 Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University Busan 48513 Republic of Korea., Harunsani MH; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link Gadong BE 1410 Brunei Darussalam mmansoobkhan@yahoo.com mansoob.khan@ubd.edu.bn., Ahmad N; Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link Gadong BE 1410 Brunei Darussalam., Kim YM; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University Busan 48513 Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University Busan 48513 Republic of Korea.; Department of Food Science and Technology, Pukyong National University Busan 48513 Republic of Korea., Jung WK; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University Busan 48513 Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University Busan 48513 Republic of Korea.; Major of Biomedical Engineering, Division of Smart Healthcare and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University Busan 48513 Republic of Korea., Khan MM; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link Gadong BE 1410 Brunei Darussalam mmansoobkhan@yahoo.com mansoob.khan@ubd.edu.bn.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 May 22; Vol. 13 (23), pp. 15421-15436. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023).
DOI:	10.1039/d3ra02474a
Abstrakt:	Cerium oxide (CeO 2 ) nanoparticles (NPs) were synthesized using a modified conventional polyol method. The ratio of diethylene glycol (DEG) and water in the synthesis was varied, and three different cerium precursor salts (Ce(NO 3 ) 3 , CeCl 3 , and Ce(CH 3 COO) 3 ) were used. The structure, size, and morphology of the synthesized CeO 2 NPs were studied. An average crystallite size of 13 to 33 nm was obtained from the XRD analysis. Spherical and elongated morphologies of the synthesized CeO 2 NPs were acquired. Average particle sizes in the range of 16-36 nm were obtained by varying different ratios of DEG and water. The presence of DEG molecules on the surface of CeO 2 NPs was confirmed using FTIR. Synthesized CeO 2 NPs were used to study the antidiabetic and cell viability (cell cytotoxicity) properties. Antidiabetic studies were carried out using α-glucosidase enzymes inhibition activity. CeO 2 synthesized using Ce(NO 3 ) 3 and CeCl 3 precursors showed approximately 40.0% α-glucosidase enzyme inhibition activity, while CeO 2 synthesized using Ce(CH 3 COO) 3 showed the lowest α-glucosidase enzyme inhibition activity. Cell viability properties of CeO 2 NPs were investigated using an in vitro cytotoxicity test. CeO 2 NPs prepared using Ce(NO 3 ) 3 and CeCl 3 were non-toxic at lower concentrations, while CeO 2 NPs prepared using Ce(CH 3 COO) 3 were non-toxic at all concentrations. Therefore, polyol-mediated synthesized CeO 2 NPs showed quite good α-glucosidase inhibition activity and biocompatibility. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu