| Autor: |
Duong TK; Department of Chemistry-Biochemistry Fundamental, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Nguyen NN; Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen NT; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam., Tran HD; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam., Nguyen KP; Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen TH; Faculty of Basic Sciences, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Vo TN; Department of Chemical Technology, Ho Chi Minh University of Technology and Education, Ho Chi Minh City, Vietnam., Nguyen TA; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam. |
| Abstrakt: |
A new pregnane steroid, jasminanthoside ( 1 ), together with three known compounds, telosmoside A7 ( 2 ), syringaresinol ( 3 ), and methyl 6-deoxy-3- O -methyl- β -D-allopyranosyl-(1→4)- β -D-oleandropyranoside ( 4 ) were isolated from the ethyl acetate extract of Jasminanthes tuyetanhiae roots collected in Vietnam. Their chemical structures were elucidated by NMR and MS spectroscopic data analysis along with the comparison of their data with the published ones in the literature. Although 4 was a known compound, its full NMR data were reported for the first time. All isolated compounds, evaluated for their α-glucosidase inhibition, showed activities stronger than the positive control acarbose. Among them, 1 was the best with the IC 50 value of 7.41 ± 0.59 µM. |
