Ant venoms contain vertebrate-selective pain-causing sodium channel toxins.

Autor: Robinson SD; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia. sam.robinson@uq.edu.au., Deuis JR; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia., Touchard A; CNRS, UMR Ecologie des forêts de Guyane (EcoFoG), Campus Agronomique; BP 316, 97379, Kourou, Cedex, France.; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France., Keramidas A; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia., Mueller A; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia., Schroeder CI; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.; Genentech, 1 DNA Way, South San Francisco, 94080, CA, USA., Barassé V; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France., Walker AA; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia., Brinkwirth N; Nanion Technologies, Munich, 80339, Germany., Jami S; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia., Bonnafé E; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France., Treilhou M; Equipe BTSB-EA 7417, Université de Toulouse, Institut National Universitaire Jean-François Champollion; Place de Verdun, 81012, Albi, France., Undheim EAB; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.; Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, The University of Oslo, Oslo, Norway.; Centre for Advanced Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia., Schmidt JO; Southwestern Biological Institute, Tucson, AZ 85745, USA.; Department of Entomology, University of Arizona, Tucson, AZ 85721, USA., King GF; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, University of Queensland, Saint Lucia, QLD 4072, Australia., Vetter I; Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia. i.vetter@imb.uq.edu.au.; School of Pharmacy, University of Queensland, Wooloongabba, QLD 4102, Australia. i.vetter@imb.uq.edu.au.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 May 23; Vol. 14 (1), pp. 2977. Date of Electronic Publication: 2023 May 23.
DOI: 10.1038/s41467-023-38839-1
Abstrakt: Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (Na V ) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
(© 2023. The Author(s).)
Databáze: MEDLINE
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