Racial disparities in nephrectomy and mortality among patients with renal cell carcinoma: Findings from SEER.

Autor:	Ikuemonisan J; Division of Tobacco Research and Prevention, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America., Aremu TO; Department of Pharmaceutical Care & Health Systems (PCHS), University of Minnesota, Minneapolis, Minnesota, United States of America.; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.; Masonic Children's Hospital, University of Minnesota, Minneapolis, Minnesota, United States of America., Oyejinmi I; Hospital Data and Analytics, HealthPartners, St Louis Park, Minnesota, United States of America., Ajala C; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America., Anikpezie N; Department of Population Health Science, The University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Akinso O; Department of Public Health, Nova SouthEastern University, Fort Lauderdale, Florida, United States of America., Mtengwa M; Department of women's Health, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America., David A; Department of Nursing, Indiana Wesleyan University, Marion, Indiana, United States of America., Olokede O; F. Maie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America., Adejoro O; Market Access, Janssen Global Services, LLC, Horsham, Philadelphia, United States of America.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2023 May 23; Vol. 3 (5), pp. e0001314. Date of Electronic Publication: 2023 May 23 (Print Publication: 2023).
DOI:	10.1371/journal.pgph.0001314
Abstrakt:	Purpose: To assess racial differences in the receipt of nephrectomy in patients diagnosed RCC in the US. Materials and Methods: 2005 to 2015 data from the SEER database was analyzed and 70,059 patients with RCC were identified. We compared demographic and tumor characteristics between black patients and white patients. We applied logistic regression to assess the association between race and the odds of the receipt of nephrectomy. We also applied Cox proportional hazards model to assess the impact of race on cancer-specific mortality (CSM) and all-cause mortality (ACM) in patients diagnosed with RCC in the US. Results: Black patients had 18% lower odds of receiving nephrectomy compared to white patients (p < 0.0001). The odds of the receipt of nephrectomy also reduced with age at diagnosis. In addition, patients with T3 stage had the greatest odds of receiving nephrectomy when compared to T1 (p < 0.0001). There was no difference in the risk of cancer-specific mortality between black patients and white patients; black patients had 27% greater odds of all-cause mortality than white patients (p < 0.0001). Patients who did not receive nephrectomy had a 42% and 35% higher risk of CSM and ACM respectively, when compared to patients who received nephrectomy. Conclusions: Black patients diagnosed with RCC in the US have a greater ACM risk and are less likely than white patients to receive nephrectomy. Systemic changes are needed to eliminate racial disparity in the treatment and outcomes of RCC in the US. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2023 Ikuemonisan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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