| Autor: |
Wickramasinghe VP; Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Wijayawardhana KWSM; Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Arambepola C; Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. |
| Jazyk: |
angličtina |
| Zdroj: |
Metabolic syndrome and related disorders [Metab Syndr Relat Disord] 2023 Jun; Vol. 21 (5), pp. 254-260. Date of Electronic Publication: 2023 May 23. |
| DOI: |
10.1089/met.2022.0086 |
| Abstrakt: |
Objective: Prevalence of insulin resistance (IR) among South Asian populations is relatively high. It increases with the obesity epidemic. Since determining IR is costly, triglyceride to high-density lipoprotein (TG/HDL) ratio has shown to be a good proxy marker for IR in adults. However, it is not yet well established in children. This study aimed to assess TG/HDL ratio as a marker of IR in 5-15-year-old children in Colombo District of Sri Lanka. Methods: A cross-sectional descriptive study was conducted among 309 school children 5-15 years of age, selected using two-stage probability-proportionate-to-size cluster sampling technique. Sociodemographic data, and anthropometric and biochemical parameters were obtained. After a 12-hr overnight fast, blood was taken for biochemical investigations. Results: Three hundred nine children (173 girls) were recruited. Mean age of girls was 9.9 years and boys 10.3 years. Based on body mass index (BMI) z-score, 15.3% were overweight and 6.1% were obese. Metabolic syndrome was present in 2.3% of children and IR based on Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) ≥2.5 in 7.5%. Mean TG/HDL ratio, waist circumference (WC), hip circumference (HC), BMI, waist-to-height-ratio (WHtR), and body fat percentage were significantly higher ( P < 0.01) among children with IR compared with non-IR children. TG/HDL ratio significantly correlated with BMI, % fat mass, WC, HC, WHtR, and HOMA-IR. TG/HDL ratio is an independent risk factor in determining IR. The cutoff value of TG/HDL ratio ≥3 had higher specificity (89.8%) but lower sensitivity (47.8%) for detection of IR. TG/HDL ratio >1.5 had a higher sensitivity (82.6%) but lower specificity (47.7%). Conclusions: TG/HDL ratio is a good proxy marker of IR among 5-15-year-old children. A cutoff value of ≥1.5 had satisfactory sensitivity and specificity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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