Role of non-coding RNAs in neuroblastoma.

Autor: Anoushirvani AA; Department of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Jafarian Yazdi A; Neurology Department, Kashan University of Medical Sciences, Kashan, Iran., Amirabadi S; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran., Asouri SA; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University, Kashan, Iran., Shafabakhsh R; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University, Kashan, Iran., Sheida A; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Hosseini Khabr MS; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran., Jafari A; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tamehri Zadeh SS; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa., Kalantari L; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Leilakln284@gmail.com., Talaei Zavareh SA; Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. talaeizavareh@gmail.com., Mirzaei H; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University, Kashan, Iran. h.mirzaei2002@gmail.com.
Jazyk: angličtina
Zdroj: Cancer gene therapy [Cancer Gene Ther] 2023 Sep; Vol. 30 (9), pp. 1190-1208. Date of Electronic Publication: 2023 May 22.
DOI: 10.1038/s41417-023-00623-0
Abstrakt: Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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