Retrospective evaluation of wobbly hedgehog syndrome in 49 African pygmy hedgehogs (Atelerix albiventris): 2000-2020.

Autor:	Gonzalez GA; 1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC., Balko JA; 2Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC., Sadar MJ; 3Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO., Alexander AB; 4Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL., Sheldon JD; 5Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN., Doss GA; 6Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI., Keller KA; 7Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL., Gardhouse SM; 8Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS., Petritz OA; 1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Jazyk:	angličtina
Zdroj:	Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2023 May 19; Vol. 261 (9), pp. 1-6. Date of Electronic Publication: 2023 May 19 (Print Publication: 2023).
DOI:	10.2460/javma.23.03.0167
Abstrakt:	Objective: To retrospectively evaluate the prevalence and clinical progression of wobbly hedgehog syndrome (WHS) and concurrent incidence of neoplasia in a cohort of African pygmy hedgehogs (Atelerix albiventris). Animals: 49 hedgehogs. Clinical Presentation and Procedures: Medical records of hedgehogs from 7 institutions across the US over a 20-year period (2000 to 2020) were retrospectively reviewed. Inclusion criteria were hedgehogs of any sex or age with postmortem CNS histopathology consistent with WHS. Collected data included sex, age at onset and euthanasia, major histopathologic findings, reported neurologic clinical signs, and treatments administered. Results: 24 males and 25 females were included. Fifteen of 49 (31%) individuals had subclinical WHS with no reported antemortem neurologic clinical signs. In neurologically affected (clinical) hedgehogs (n = 34), the mean ± SD age at onset was 3.3 ± 1.5 years with a median (range) time from onset to euthanasia of 51 days (1 to 319 days). In neurologically affected hedgehogs, the most commonly reported clinical signs were ataxia (n = 21) and pelvic limb paresis (16) and the most commonly administered treatment was meloxicam (13). Overall, 31 of 49 (63%) hedgehogs had a concurrent histopathologic diagnosis of neoplasia outside of the CNS. Clinical Relevance: The prognosis for hedgehogs with WHS is poor. No treatment had a significant effect on survival time, and neoplasia was a common comorbidity in the current cohort. A small but clinically relevant subset of neurologically normal hedgehogs had a histopathologic diagnosis of WHS.
Databáze:	MEDLINE
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