Non-invasive STEMI-related biomarkers based on meta-analysis and gene prioritization.

Autor: Sheikh Beig Goharrizi MA; University of Tehran, Tehran, Iran. Electronic address: Msheikhbeig@ut.ac.ir., Ghodsi S; Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences Tehran, Iran., Mokhtari M; Department of Bioinformatics, Kish International Campus, University of Tehran, Kish Island, Iran; Laboratory of Personalized Precision Medicine, Bioinformatics Research Institute, Tehran, Iran., Moravveji SS; Department of Bioinformatics, Kish International Campus, University of Tehran, Kish Island, Iran.
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2023 Jul; Vol. 161, pp. 106997. Date of Electronic Publication: 2023 May 05.
DOI: 10.1016/j.compbiomed.2023.106997
Abstrakt: Background and Aims: Acute ST-Segment Myocardial infarction (STEMI) is a common cardiovascular issue with a considerable burden of the disease. The underlying genetic basis and non-invasive markers were not well-established.
Methods: Here, we implemented a systematic literature review and meta-analyses integration methods on 217 STEMI patients and 72 normal individuals to prioritize and detect the STEMI-related non-invasive markers. Five high-scored genes were experimentally assessed on 10 STEMI patients and 9 healthy controls. Finally, the presence of co-expressed nodes of top-score genes was explored.
Results: The differential expression of ARGL, CLEC4E, and EIF3D were significant for Iranian patients. The ROC curve for gene CLEC4E revealed an AUC (95% CI) of 0.786 (0.686-0.886) in the prediction of STEMI. The Cox-PH model was fitted to stratify high/low risk heart failure progression (CI-index = 0.83, Likelihood-Ratio-Test = 3e-10). The SI00AI2 was a common biomarker between STEMI and NSTEMI patients.
Conclusions: In conclusion, the high-scored genes and prognostic model could be applicable for Iranian patients.
Competing Interests: Declaration of competing interest “None Declared”. All authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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