B cells in tumor metastasis: friend or foe?

Autor:	Xu Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Mao Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Lv Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Tang W; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Xu J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jazyk:	angličtina
Zdroj:	International journal of biological sciences [Int J Biol Sci] 2023 Apr 29; Vol. 19 (8), pp. 2382-2393. Date of Electronic Publication: 2023 Apr 29 (Print Publication: 2023).
DOI:	10.7150/ijbs.79482
Abstrakt:	Metastasis is an important cause of cancer-related death. Immunotherapy may be an effective way to prevent and treat tumor metastasis in the future. Currently, many studies have focused on T cells, whereas fewer have focused on B cells and their subsets. B cells play an important role in tumor metastasis. They not only secrete antibodies and various cytokines but also function in antigen presentation to directly or indirectly participate in tumor immunity. Furthermore, B cells are involved in both inhibiting and promoting tumor metastasis, which demonstrates the complexity of B cells in tumor immunity. Moreover, different subgroups of B cells have distinct functions. The functions of B cells are also affected by the tumor microenvironment, and the metabolic homeostasis of B cells is also closely related to their function. In this review, we summarize the role of B cells in tumor metastasis, analyze the mechanisms of B cells, and discuss the current status and prospects of B cells in immunotherapy. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).)
Databáze:	MEDLINE
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