Oxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina.

Autor:	Inague A; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Alecrim LC; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Monteiro JS; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Yoshinaga MY; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Setubal JC; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Miyamoto S; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil., Giordano RJ; Biochemistry Department, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP 05508-000, Brazil.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2023 May 04; Vol. 26 (6), pp. 106777. Date of Electronic Publication: 2023 May 04 (Print Publication: 2023).
DOI:	10.1016/j.isci.2023.106777
Abstrakt:	The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients, and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and pathological angiogenesis using the oxygen-induced retinopathy model. By matching lipid profiles to changes in mRNA transcriptome, we identified a lipid signature showing that pathological angiogenesis leads to intense lipid remodeling favoring pathways for neutral lipid synthesis, cholesterol import/export, and lipid droplet formation. Noteworthy, it also shows profound changes in pathways for long-chain fatty acid production, vital for retina homeostasis. The net result is accumulation of large quantities of mead acid, a marker of essential fatty acid deficiency, and a potential marker for retinopathy severity. Thus, our lipid signature might contribute to better understand diseases of the retina that lead to vision impairment or blindness. Competing Interests: The authors declare no competing interests. (© 2023.)
Databáze:	MEDLINE
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