Human papillomavirus infection and non-oropharyngeal head and neck cancers: an umbrella review of meta-analysis.

Autor: Petrelli F; Oncology Unit, Medical Sciences Department, ASST Bergamo Ovest, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy. faupe@libero.it., Cin ED; ENT Unit, Head and Neck Department, Mestre Hospital, ULSS 3, Venice, VE, Italy., Ghidini A; Oncology Unit, Casa Di Cura Igea, Milan, Italy., Carioli D; Otorhinolaringology Unit, Department of Neuroscience, ASST Bergamo Ovest, Treviglio, BG, Italy., Falasca V; Otorhinolaringology Unit, Department of Neuroscience, ASST Bergamo Ovest, Treviglio, BG, Italy., De Stefani A; Radiotherapy Unit, ASST Bergamo Ovest, Treviglio, BG, Italy., Moleri G; Ufficio Relazioni Col Pubblico, ASST Bergamo Ovest, Treviglio, BG, Italy., Ardito R; IRCCS Centro Di Riferimento Oncologico Della Basilicata (CROB), Oncological Day Hospital, Via Padre Pio 1, 85028, Rionero in Vulture, PZ, Italy., Luciani A; Oncology Unit, Medical Sciences Department, ASST Bergamo Ovest, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy., Nardone M; Otorhinolaringology Unit, Department of Neuroscience, ASST Bergamo Ovest, Treviglio, BG, Italy., Capriotti V; Otorhinolaringology Unit, Department of Neuroscience, ASST Bergamo Ovest, Treviglio, BG, Italy.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2023 Sep; Vol. 280 (9), pp. 3921-3930. Date of Electronic Publication: 2023 May 22.
DOI: 10.1007/s00405-023-08027-4
Abstrakt: Objective: The causative and prognostic roles of human papillomavirus (HPV) in non-oropharyngeal squamous cell carcinoma of the head and neck are uncertain. This umbrella review assessed the strength and quality of evidence and graded the evidence derived from published meta-analyses on this subject.
Data Sources: MEDLINE, Embase, and the Cochrane Library were searched. Meta-analyses of observational studies and randomized trials were included.
Review Methods: Evidence of association was graded according to the established criteria: strong, highly suggestive, suggestive, weak, or not significant.
Results: 15 meta-analyses were evaluated. The association with HPV was highly suggestive of oral (OR = 2.40, [1.87-3.07], P < 0.00001) and nasopharyngeal cancers (OR = 17.82 [11.20-28.35], P < 0.00001). Improved survival emerged only in hypopharyngeal carcinoma and was confirmed in studies in which only p16 + cancers were considered.
Conclusion: HPV infection may increase the risk of oral cavity and nasopharyngeal cancer. However, the prognosis was not influenced, except in hypopharyngeal carcinoma.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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