RNA binding proteins in senescence: A potential common linker for age-related diseases?

Autor: Varesi A; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy. Electronic address: angelica.varesi01@universitadipavia.it., Campagnoli LIM; Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy., Barbieri A; Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy., Rossi L; Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Ricevuti G; Department of Drug Sciences, University of Pavia, Pavia, Italy., Esposito C; Department of Internal Medicine and Therapeutics, University of Pavia, Italy; Nephrology and dialysis unit, ICS S. Maugeri SPA SB Hospital, Pavia, Italy; High School in Geriatrics, University of Pavia, Italy., Chirumbolo S; Department of Neurological and Movement Sciences, University of Verona, Italy., Marchesi N; Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy., Pascale A; Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy. Electronic address: alessia.pascale@unipv.it.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2023 Jul; Vol. 88, pp. 101958. Date of Electronic Publication: 2023 May 19.
DOI: 10.1016/j.arr.2023.101958
Abstrakt: Aging represents the major risk factor for the onset and/or progression of various disorders including neurodegenerative diseases, metabolic disorders, and bone-related defects. As the average age of the population is predicted to exponentially increase in the coming years, understanding the molecular mechanisms underlying the development of aging-related diseases and the discovery of new therapeutic approaches remain pivotal. Well-reported hallmarks of aging are cellular senescence, genome instability, autophagy impairment, mitochondria dysfunction, dysbiosis, telomere attrition, metabolic dysregulation, epigenetic alterations, low-grade chronic inflammation, stem cell exhaustion, altered cell-to-cell communication and impaired proteostasis. With few exceptions, however, many of the molecular players implicated within these processes as well as their role in disease development remain largely unknown. RNA binding proteins (RBPs) are known to regulate gene expression by dictating at post-transcriptional level the fate of nascent transcripts. Their activity ranges from directing primary mRNA maturation and trafficking to modulation of transcript stability and/or translation. Accumulating evidence has shown that RBPs are emerging as key regulators of aging and aging-related diseases, with the potential to become new diagnostic and therapeutic tools to prevent or delay aging processes. In this review, we summarize the role of RBPs in promoting cellular senescence and we highlight their dysregulation in the pathogenesis and progression of the main aging-related diseases, with the aim of encouraging further investigations that will help to better disclose this novel and captivating molecular scenario.
Competing Interests: Declaration of Competing Interest The authors have declared no conflict of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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