First description of Candida haemulonii infecting a snake Boa constrictor: Molecular, pathological and antifungal sensitivity characteristics.

Autor:	Fonseca MS; Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil., Deegan KR; Ambulatório de Animais Silvestres e Exóticos, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia State, 40170-1004, Brazil., Tomé LM; Laboratório de Biologia Molecular e Computacional de Fungos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, 31270-901, Brazil., Mendonça MA; Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil., Sokolonski AR; Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil., Gondim LQ; Ambulatório de Animais Silvestres e Exóticos, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia State, 40170-1004, Brazil., Azevedo V; Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, 31270-901, Brazil., Meyer R; Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil., Tasic L; Laboratório de Química Biológica, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de Campinas, Campinas, São Paulo State, 13083-970, Brazil., Góes-Neto A; Laboratório de Biologia Molecular e Computacional de Fungos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, 31270-901, Brazil., Portela RW; Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil. Electronic address: rwportela@ufba.br.
Jazyk:	angličtina
Zdroj:	Microbial pathogenesis [Microb Pathog] 2023 Jul; Vol. 180, pp. 106164. Date of Electronic Publication: 2023 May 19.
DOI:	10.1016/j.micpath.2023.106164
Abstrakt:	Candida haemulonii is an emergent infectious pathogen that affects human presenting comorbidities and/or immunodepression. Little is known about other possible hosts. For the first time, this fungus was found causing a cutaneous infection in a snake, Boa constrictor, characterized by scale opacity and several ulcerative lesions. This C. haemulonii was isolated, identified using molecular techniques and a phylogenetic study, and had its growth totally inhibited by all the drugs tested; however, no fungicide effect was seen for fluconazole and itraconazole. The B. constrictor clinical signals subsided after a treatment using a biogenic silver nanoparticle-based ointment. These findings, along with the B. constrictor presence near human habitats, warn for the necessity of wildlife health monitoring for emergent and opportunistic diseases in peri-urban environments. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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