Free light chains as a reliable biomarker of intrathecal synthesis in the diagnosis of CNS inflammatory diseases.

Autor: Michetti L; Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy. Electronic address: lmichetti@asst-pg23.it., Maffina F; Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Ravasio R; Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Barcella V; Department of Neurology and Multiple Sclerosis Center, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Radaelli M; Department of Neurology and Multiple Sclerosis Center, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Chiudinelli L; Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Sessa M; Department of Neurology and Multiple Sclerosis Center, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy., Alessio MG; Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2023 Jun 15; Vol. 379, pp. 578091. Date of Electronic Publication: 2023 Apr 22.
DOI: 10.1016/j.jneuroim.2023.578091
Abstrakt: Objective: To address the diagnostic performances of cerebrospinal fluid (CSF) free light chains (FLC) measurements compared to oligoclonal bands (OCB) to support multiple sclerosis (MS) diagnosis.
Results: kFLC index showed the highest diagnostic accuracy to detect MS patients with the highest AUC compared to OCB, IgG index, IF kFLC R, kFLC H, λFLC index and IF λFLC.
Conclusions: FLC indices are biomarkers of intrathecal Immunoglobulin synthesis and central nervous system (CNS) inflammation. kFLC index can discriminate between MS and other CNS inflammatory disorders, while λFLC index is less informative for MS but can play a role to support the diagnosis of other inflammatory CNS disorders.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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