Computation of physiological loading induced interstitial fluid motion in muscle standardized femur: Healthy vs. osteoporotic bone.

Autor: Shrivas NV; Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India; Department of Mechatronics Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India., Badhyal S; Bubba Watson and PING Golf Motion Analysis Laboratory, Herbert J Louis Center for Pediatric Orthopedics, Phoenix Children...s Hospital, Phoenix, Arizona, 85016, USA., Tiwari AK; Department of Applied Mechanics, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh 211004, India., Mishra A; Department of Applied Mechanics, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh 211004, India., Tripathi D; Department of Mathematics, National Institute of Technology Uttarakhand, Srinagar, Uttarakhand 246174, India. Electronic address: dtripathi@nituk.ac.in., Patil S; Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India.
Jazyk: angličtina
Zdroj: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2023 Jul; Vol. 237, pp. 107592. Date of Electronic Publication: 2023 May 09.
DOI: 10.1016/j.cmpb.2023.107592
Abstrakt: Background and Objectives: Physiological loading-induced mechanical environments regulate bone modeling and remodeling. Thus, loading-induced normal strain is typically considered a stimulus to osteogenesis. However, several studies noticed new bone formation near the sites of minimal normal strain, e.g., the neutral axis of bending in long bones, which raises a question on how bone mass is maintained near these sites. Secondary mechanical components such as shear strain and interstitial fluid flow also stimulate bone cells and regulate bone mass. However, the osteogenic potential of these components is not well established. Accordingly, the present study estimates the distribution of physiological muscle loading-induced mechanical environments such as normal strain, shear strain, pore pressure, and interstitial fluid flow in long bones.
Methods: A poroelastic finite element muscle standardized femur (MuscleSF) model is developed to compute the distribution of the mechanical environment as a function of bone porosities associated with osteoporotic and disuse bone loss.
Results: The results indicate the presence of higher shear strain and interstitial fluid motion near the minimal strain sites, i.e., the neutral axis of bending of femoral cross-sections. This suggests that secondary stimuli may maintain the bone mass at these locations. Pore pressure and interstitial fluid motion reduce with the increased porosity associated with bone disorders, possibly resulting in diminished skeletal mechano-sensitivity to exogenous loading.
Conclusions: These outcomes present a better understanding of mechanical environment-mediated regulation of site-specific bone mass, which can be beneficial in developing prophylactic exercise to prevent bone loss in osteoporosis and muscle disuse.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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