Development and Validation of the Dystonia-Pain Classification System: A Multicenter Study.

Autor: Listik C; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., Listik E; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., de Paiva Santos Rolim F; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil., Meneses Cury Portela DM; Department of Neurology, Instituto de Ensino Superior do Piaui, Teresina, Brazil., Perez Lloret S; Observatorio de Salud Pública, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina.; Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina., de Alves Araújo NR; Department of Neurology, Instituto de Ensino Superior do Piaui, Teresina, Brazil., Carvalho PRA; Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, Brazil., Santos GC; Department of Neurology, Universidade Federal de Sao Paulo (UNIFESP), São Paulo, Brazil., Limongi JCP; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., Cardoso F; Department of Neurology, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Mylius V; Department of Neurology, Center for Neurorehabilitation, Valens, Switzerland.; Department of Neurology, Philipps University, Marburg, Germany., Brugger F; Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland., Fernandes AM; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., Reis Barbosa E; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., Jacobsen Teixeira M; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., Ferraz HB; Department of Neurology, Universidade Federal de Sao Paulo (UNIFESP), São Paulo, Brazil., Camargos ST; Department of Neurology, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Cury RG; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil., de Andrade DC; Department of Neurology, Movement Disorders Center, School of Medicine, University of São Paulo, São Paulo, Brazil.; Department of Health Science and Technology, Center for Neuroplasticity and Pain (CNAP), Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Jul; Vol. 38 (7), pp. 1163-1174. Date of Electronic Publication: 2023 May 20.
DOI: 10.1002/mds.29423
Abstrakt: Background: Dystonia is associated with disabling nonmotor symptoms like chronic pain (CP), which is prevalent in dystonia and significantly impacts the quality of life (QoL). There is no validated tool for assessing CP in dystonia, which substantially hampers pain management.
Objective: The aim was to develop a CP classification and scoring system for dystonia.
Methods: A multidisciplinary group was established to develop the Dystonia-Pain Classification System (Dystonia-PCS). The classification of CP as related or unrelated to dystonia was followed by the assessment of pain severity score, encompassing pain intensity, frequency, and impact on daily living. Then, consecutive patients with inherited/idiopathic dystonia of different spatial distribution were recruited in a cross-sectional multicenter validation study. Dystonia-PCS was compared to validated pain, mood, QoL, and dystonia scales (Brief Pain Inventory, Douleur Neuropathique-4 questionnaire, European QoL-5 Dimensions-3 Level Version, and Burke-Fahn-Marsden Dystonia Rating Scale).
Results: CP was present in 81 of 123 recruited patients, being directly related to dystonia in 82.7%, aggravated by dystonia in 8.8%, and nonrelated to dystonia in 7.5%. Dystonia-PCS had excellent intra-rater (Intraclass Correlation Coefficient - ICC: 0.941) and inter-rater (ICC: 0.867) reliability. In addition, pain severity score correlated with European QoL-5 Dimensions-3 Level Version's pain subscore (r = 0.635, P < 0.001) and the Brief Pain Inventory's severity and interference scores (r = 0.553, P < 0.001 and r = 0.609, P < 0.001, respectively).
Conclusions: Dystonia-PCS is a reliable tool to categorize and quantify CP impact in dystonia and will help improve clinical trial design and management of CP in patients affected by this disorder. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
(© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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