Dactylides A-C, three new bioactive 22-membered macrolides produced by Dactylosporangium aurantiacum.

Autor: Kumar P; Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, 364002, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Nalli Y; Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, 364002, India., Singh S; Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, 364002, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Wakchaure PD; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Computation and Simulation Unit, Analytical and Environmental Science Division and Centralized Instrument Facility, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, 364002, India., Gor R; Department of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India., Ghadge VA; Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, 364002, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Kim E; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Ramalingam S; Department of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India., Azger Dusthackeer VN; Department of Bacteriology, National Institute for Research in Tuberculosis, ICMR, Sathyamoorty road, Chetpet, Chennai, 600031, Tamil Nadu, India., Yoon YJ; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Ganguly B; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Computation and Simulation Unit, Analytical and Environmental Science Division and Centralized Instrument Facility, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, 364002, India., Shinde PB; Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, 364002, India. pramodshinde@csmcri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. pramodshinde@csmcri.res.in.
Jazyk: angličtina
Zdroj: The Journal of antibiotics [J Antibiot (Tokyo)] 2023 Sep; Vol. 76 (9), pp. 503-510. Date of Electronic Publication: 2023 May 19.
DOI: 10.1038/s41429-023-00632-z
Abstrakt: Three new 22-membered polyol macrolides, dactylides A-C (1-3), were isolated from Dactylosporangium aurantiacum ATCC 23491 employing repeated chromatographic separations, and their structures were established based on detailed analysis of NMR and MS data. The relative configurations at the stereocenters were established via vicinal 1 H- 1 H coupling constants, NOE correlations, and by application of Kishi's universal NMR database. In order to get insights into the biosynthetic pathway of 1-3, the genome sequence of the producer strain D. aurantiacum was obtained and the putative biosynthetic gene cluster encoding their biosynthesis was identified through bioinformatic analysis using antiSMASH. Compounds 1-3 showed significant in-vitro antimycobacterial and cytotoxic activity.
(© 2023. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)
Databáze: MEDLINE
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