A review of neurophysiological effects and efficiency of waveform parameters in deep brain stimulation.

Autor: Gilbert Z; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States. Electronic address: zgilbert@usc.edu., Mason X; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States., Sebastian R; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Tang AM; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Martin Del Campo-Vera R; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Chen KH; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Leonor A; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Shao A; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Tabarsi E; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Chung R; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Sundaram S; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Kammen A; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Cavaleri J; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Gogia AS; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Heck C; Department of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States., Nune G; Department of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States., Liu CY; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; Department of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States., Kellis SS; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States., Lee B; Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, United States.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2023 Aug; Vol. 152, pp. 93-111. Date of Electronic Publication: 2023 May 08.
DOI: 10.1016/j.clinph.2023.04.007
Abstrakt: Neurostimulation has diverse clinical applications and potential as a treatment for medically refractory movement disorders, epilepsy, and other neurological disorders. However, the parameters used to program electrodes-polarity, pulse width, amplitude, and frequency-and how they are adjusted have remained largely untouched since the 1970 s. This review summarizes the state-of-the-art in Deep Brain Stimulation (DBS) and highlights the need for further research to uncover the physiological mechanisms of neurostimulation. We focus on studies that reveal the potential for clinicians to use waveform parameters to selectively stimulate neural tissue for therapeutic benefit, while avoiding activating tissue associated with adverse effects. DBS uses cathodic monophasic rectangular pulses with passive recharging in clinical practice to treat neurological conditions such as Parkinson's Disease. However, research has shown that stimulation efficiency can be improved, and side effects reduced, through modulating parameters and adding novel waveform properties. These developments can prolong implantable pulse generator lifespan, reducing costs and surgery-associated risks. Waveform parameters can stimulate neurons based on axon orientation and intrinsic structural properties, providing clinicians with more precise targeting of neural pathways. These findings could expand the spectrum of diseases treatable with neuromodulation and improve patient outcomes.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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