Trichinocidal activity of a novel formulation of curcumin-olive oil nanocomposite in vitro.
Autor: | Khalifa MM; Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, 1221 Giza, Egypt., Ramadan RM; Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, 1221 Giza, Egypt. Electronic address: reem.montaser@cu.edu.eg., Youssef FS; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Egypt., Auda HM; Department of Medicine & Infectious Diseases, Faculty of Vet. Medicine, Cairo University, Egypt., El-Bahy MM; Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, 1221 Giza, Egypt., Taha NM; Department of Parasitology, Faculty of Medicine, Cairo University, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2023 Jun; Vol. 41, pp. 100880. Date of Electronic Publication: 2023 Apr 15. |
DOI: | 10.1016/j.vprsr.2023.100880 |
Abstrakt: | Curcumin-olive oil nanocomposite (CO-NC), a novel formulation of nano-curcumin, was produced and characterized. By evaluating the death rate and DNA damage inflicted on adult Trichinella spiralis (T. spiralis) worms using the comet test and Scanning electron microscopy (SEM) analysis, the effectiveness of the substance against these worms was assessed in vitro. The mortality effects of CO-NC on the parasite adult worms were increased with the upgrading in the concentration and exposure time from 1 to 24 h using concentrations from 10 to 100 ppm. LC Competing Interests: Declaration of Competing Interest There are no declared conflicts of interest. The corresponding author is ready to provide any detailed data upon request. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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