Increased Levels of Inflammatory and Endothelial Biomarkers in Blood of Long COVID Patients Point to Thrombotic Endothelialitis.

Autor:	Turner S; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Naidoo CA; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Usher TJ; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Kruger A; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Venter C; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Laubscher GJ; Mediclinic Stellenbosch, Stellenbosch, South Africa., Khan MA; Department of Respiratory Medicine, Wythenshawe Hospital, Manchester University, Manchester, United Kingdom., Kell DB; Department of Biochemistry and Systems Biology; Institute of Systems, Molecular and Integrative Biology; Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.; Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kemitorvet Lyngby, Denmark., Pretorius E; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.; Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kemitorvet Lyngby, Denmark.
Jazyk:	angličtina
Zdroj:	Seminars in thrombosis and hemostasis [Semin Thromb Hemost] 2024 Mar; Vol. 50 (2), pp. 288-294. Date of Electronic Publication: 2023 May 19.
DOI:	10.1055/s-0043-1769014
Abstrakt:	The prevailing hypotheses for the persistent symptoms of Long COVID have been narrowed down to immune dysregulation and autoantibodies, widespread organ damage, viral persistence, and fibrinaloid microclots (entrapping numerous inflammatory molecules) together with platelet hyperactivation. Here we demonstrate significantly increased concentrations of von Willebrand factor (VWF), platelet factor 4 (PF4), serum amyloid A (SAA), α-2 antiplasmin (α-2AP), endothelial-leukocyte adhesion molecule 1 (E-selectin), and platelet endothelial cell adhesion molecule (PECAM-1) in the soluble part of the blood. It was noteworthy that the mean level of α-2 antiplasmin exceeded the upper limit of the laboratory reference range in Long COVID patients, and the other 5 were significantly elevated in Long COVID patients as compared to the controls. This is alarming if we take into consideration that a significant amount of the total burden of these inflammatory molecules has previously been shown to be entrapped inside fibrinolysis-resistant microclots (thus decreasing the apparent level of the soluble molecules). We conclude that presence of microclotting, together with relatively high levels of six biomarkers known to be key drivers of endothelial and clotting pathology, points to thrombotic endothelialitis as a key pathological process in Long COVID. Competing Interests: E.P. is themanaging director of Biocode Technologies. The other authors have no competing interests to declare. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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