Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege.

Autor:	Lorrey SJ; Department of Immunology, Duke University, Durham, NC, USA.; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA., Waibl Polania J; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Wachsmuth LP; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA.; Medical Scientist Training Program, Duke University, Durham, NC, USA., Hoyt-Miggelbrink A; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Tritz ZP; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Edwards R; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA., Wolf DM; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Johnson AJ; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Fecci PE; Department of Immunology, Duke University, Durham, NC, USA.; Brain Tumor Immunotherapy Program, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA.; Department of Neurosurgery, Duke University, Durham, NC, USA., Ayasoufi K; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	Neuro-oncology advances [Neurooncol Adv] 2023 Apr 11; Vol. 5 (1), pp. vdad035. Date of Electronic Publication: 2023 Apr 11 (Print Publication: 2023).
DOI:	10.1093/noajnl/vdad035
Abstrakt:	Background: The nervous and immune systems interact in a reciprocal manner, both under physiologic and pathologic conditions. Literature spanning various CNS pathologies including brain tumors, stroke, traumatic brain injury and de-myelinating diseases describes a number of associated systemic immunologic changes, particularly in the T-cell compartment. These immunologic changes include severe T-cell lymphopenia, lymphoid organ contraction, and T-cell sequestration within the bone marrow. Methods: We performed an in-depth systematic review of the literature and discussed pathologies that involve brain insults and systemic immune derangements. Conclusions: In this review, we propose that the same immunologic changes hereafter termed 'systemic immune derangements', are present across CNS pathologies and may represent a novel, systemic mechanism of immune privilege for the CNS. We further demonstrate that systemic immune derangements are transient when associated with isolated insults such as stroke and TBI but persist in the setting of chronic CNS insults such as brain tumors. Systemic immune derangements have vast implications for informed treatment modalities and outcomes of various neurologic pathologies. Competing Interests: None. All authors have read this manuscript and agree with the statements written. (© The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)
Databáze:	MEDLINE
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