Histological and MRI brain atlas of the common shrew, Sorex araneus , with brain region-specific gene expression profiles.

Autor:	Baldoni C; Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell am Bodensee, Germany.; Department of Biology, University of Konstanz, Konstanz, Germany.; International Max Planck Research School for Quantitative Behaviour Ecology and Evolution, Konstanz, Germany., Thomas WR; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, United States., von Elverfeldt D; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Reisert M; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Làzaro J; Javier Lázaro Scientific and Wildlife Illustration, Noasca, Italy., Muturi M; Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell am Bodensee, Germany., Dávalos LM; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, United States.; Consortium for Inter-Disciplinary Environmental Research, Stony Brook University, Stony Brook, NY, United States., Nieland JD; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Dechmann DKN; Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell am Bodensee, Germany.; Department of Biology, University of Konstanz, Konstanz, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroanatomy [Front Neuroanat] 2023 May 03; Vol. 17, pp. 1168523. Date of Electronic Publication: 2023 May 03 (Print Publication: 2023).
DOI:	10.3389/fnana.2023.1168523
Abstrakt:	The common shrew, Sorex araneus , is a small mammal of growing interest in neuroscience research, as it exhibits dramatic and reversible seasonal changes in individual brain size and organization (a process known as Dehnel's phenomenon). Despite decades of studies on this system, the mechanisms behind the structural changes during Dehnel's phenomenon are not yet understood. To resolve these questions and foster research on this unique species, we present the first combined histological, magnetic resonance imaging (MRI), and transcriptomic atlas of the common shrew brain. Our integrated morphometric brain atlas provides easily obtainable and comparable anatomic structures, while transcriptomic mapping identified distinct expression profiles across most brain regions. These results suggest that high-resolution morphological and genetic research is pivotal for elucidating the mechanisms underlying Dehnel's phenomenon while providing a communal resource for continued research on a model of natural mammalian regeneration. Morphometric and NCBI Sequencing Read Archive are available at https://doi.org/10.17617/3.HVW8ZN. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Baldoni, Thomas, von Elverfeldt, Reisert, Làzaro, Muturi, Dávalos, Nieland and Dechmann.)
Databáze:	MEDLINE
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