Anatomical landscape of oral squamous cell carcinoma: A single cancer center study in UAE.

Autor:	Al-Rawi NH; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.; College of Dental Medicine, University of Sharjah, United Arab Emirates., Hachim IY; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates., Hachim MY; College of Medicine, Mohammed bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Salmeh A; College of Dental Medicine, University of Sharjah, United Arab Emirates., Uthman AT; College of Dentistry, Gulf Medical University, Ajman, United Arab Emirates., Marei H; College of Dentistry, Gulf Medical University, Ajman, United Arab Emirates.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 May 03; Vol. 9 (5), pp. e15884. Date of Electronic Publication: 2023 May 03 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e15884
Abstrakt:	Objectives: This study aimed to present demographic and clinicopathological aspects of OSCC identified in Pathology service in the UAE over a 13-year period and compare these findings to a cohort of 523 cases of Head and neck squamous cell carcinoma using the Cancer Genome Atlas's cBioPortal database (http://cbioportal.org). Material and Methods: Histological examination of all hematoxylin and eosin-stained slides and assessment of all demographic and clinical information from laboratory records were performed on all OSCC diagnosed between 2005 and 2018. Results: Males made up 71.4% of the sample of 231 OSCCs that were evaluated. The patients' average age was 55.38 years. The two most prevalent afflicted sites were the anterior two-thirds of the tongue (57.6%) and the cheek (28.1%). The most prevalent site among smokers were the floor of mouth, cheek, and jaw bones. There was a link between tumor size and numerous anatomical subsites that was shown to be highly significant. OSCC in the FOM was associated with a 25% mortality rate. Patients with OSCC of the anterior tongue and cheek had the best prognosis, with only 15.7% and 15.3% of patients dying during follow-up. Conclusion: The present investigation found a correlation between the diverse clinicopathological characteristics of the various anatomical subsites in OSCC. Different anatomical subsites also displayed varying degrees of gene mutation. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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