HIV infection and cardiovascular disease have both shared and distinct monocyte gene expression features: Women's Interagency HIV study.

Autor: Lin J; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America., Ehinger E; Department of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America., Hanna DB; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America., Wang T; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America., Ghosheh Y; Department of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America., Mueller K; Department of Cardiology, Eberhard Karls University, Tuebingen University Hospital, Tuebingen, Germany., Anastos K; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States of America., Lazar JM; Department of Medicine, Downstate Medical Center, State University of New York, Brooklyn, NY, United States of America., Mack WJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America., Tien PC; Department of Medicine, and Department of Veterans Affairs, Medical Center, University of California, San Francisco, San Francisco, CA, United States of America., Berman JW; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States of America., Cohen MH; Department of Medicine, John Stroger Hospital and Rush University, Chicago, IL, United States of America., Ofotokun I; Department of Medicine, Infectious Disease Division and Grady Health Care System, Emory University School of Medicine, Atlanta, GA, United States of America., Gange S; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America., Liu C; Department of Medicine, Georgetown University Medical Center, Washington, DC, United States of America., Heath SL; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Tracy RP; Department of Pathology & Laboratory Medicine and Biochemistry, University of Vermont Larner College of Medicine, Colchester, VT, United States of America., Hodis HN; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America., Landay AL; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America., Ley K; Department of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America.; Department of Bioengineering, University of California San Diego, San Diego, CA, United States of America., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America.; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 May 19; Vol. 18 (5), pp. e0285926. Date of Electronic Publication: 2023 May 19 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0285926
Abstrakt: Persistent inflammation contributes to the development of cardiovascular disease (CVD) as an HIV-associated comorbidity. Innate immune cells such as monocytes are major drivers of inflammation in men and women with HIV. The study objectives are to examine the contribution of circulating non-classical monocytes (NCM, CD14dimCD16+) and intermediate monocytes (IM, CD14+CD16+) to the host response to long-term HIV infection and HIV-associated CVD. Women with and without chronic HIV infection (H) were studied. Subclinical CVD (C) was detected as plaques imaged by B-mode carotid artery ultrasound. The study included H-C-, H+C-, H-C+, and H+C+ participants (23 of each, matched on race/ethnicity, age and smoking status), selected from among enrollees in the Women's Interagency HIV Study. We assessed transcriptomic features associated with HIV or CVD alone or comorbid HIV/CVD comparing to healthy (H-C-) participants in IM and NCM isolated from peripheral blood mononuclear cells. IM gene expression was little affected by HIV alone or CVD alone. In IM, coexisting HIV and CVD produced a measurable gene transcription signature, which was abolished by lipid-lowering treatment. In NCM, versus non-HIV controls, women with HIV had altered gene expression, irrespective of whether or not they had comorbid CVD. The largest set of differentially expressed genes was found in NCM among women with both HIV and CVD. Genes upregulated in association with HIV included several potential targets of drug therapies, including LAG3 (CD223). In conclusion, circulating monocytes from patients with well controlled HIV infection demonstrate an extensive gene expression signature which may be consistent with the ability of these cells to serve as potential viral reservoirs. Gene transcriptional changes in HIV patients were further magnified in the presence of subclinical CVD.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje