Gut microbiota, an emergent target to shape the efficiency of cancer therapy.

Autor:	Kouidhi S; Laboratory BVBGR-LR11ES31, Biotechnopole Sidi Thabet, University Manouba, ISBST, Ariana 2020, Tunisia.; Association Tunisienne de Lutte contre le Cancer (ATCC), Tunis, Tunisia., Zidi O; Laboratory BVBGR-LR11ES31, Biotechnopole Sidi Thabet, University Manouba, ISBST, Ariana 2020, Tunisia.; Department of Biologu, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia., Belkhiria Z; Medical Imaging Center, IBN Zohr, City El Khadhra 1003, Tunisia., Rais H; Association Tunisienne de Lutte contre le Cancer (ATCC), Tunis, Tunisia.; Service d'Oncologie Médicale, Hôpital Salah-Azaïz, Tunis 1006, Tunisia., Ayadi A; Department of Pathology, Abderrahman Mami Hospital, University of Tunis El Manar, Ariana 2080, Tunisia., Ben Ayed F; Association Tunisienne de Lutte contre le Cancer (ATCC), Tunis, Tunisia., Mosbah A; Laboratory BVBGR-LR11ES31, Biotechnopole Sidi Thabet, University Manouba, ISBST, Ariana 2020, Tunisia., Cherif A; Laboratory BVBGR-LR11ES31, Biotechnopole Sidi Thabet, University Manouba, ISBST, Ariana 2020, Tunisia., El Gaaied ABA; Laboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
Jazyk:	angličtina
Zdroj:	Exploration of targeted anti-tumor therapy [Explor Target Antitumor Ther] 2023; Vol. 4 (2), pp. 240-265. Date of Electronic Publication: 2023 Apr 26.
DOI:	10.37349/etat.2023.00132
Abstrakt:	It is now well-acknowledged that microbiota has a profound influence on both human health and illness. The gut microbiota has recently come to light as a crucial element that influences cancer through a variety of mechanisms. The connections between the microbiome and cancer therapy are further highlighted by a number of preclinical and clinical evidence, suggesting that these complicated interactions may vary by cancer type, treatment, or even by tumor stage. The paradoxical relationship between gut microbiota and cancer therapies is that in some cancers, the gut microbiota may be necessary to maintain therapeutic efficacy, whereas, in other cancers, gut microbiota depletion significantly increases efficacy. Actually, mounting research has shown that the gut microbiota plays a crucial role in regulating the host immune response and boosting the efficacy of anticancer medications like chemotherapy and immunotherapy. Therefore, gut microbiota modulation, which aims to restore gut microbial balance, is a viable technique for cancer prevention and therapy given the expanding understanding of how the gut microbiome regulates treatment response and contributes to carcinogenesis. This review will provide an outline of the gut microbiota's role in health and disease, along with a summary of the most recent research on how it may influence the effectiveness of various anticancer medicines and affect the growth of cancer. This study will next cover the newly developed microbiota-targeting strategies including prebiotics, probiotics, and fecal microbiota transplantation (FMT) to enhance anticancer therapy effectiveness, given its significance. Competing Interests: The authors declare that they have no conflicts of interest. (© The Author(s) 2023.)
Databáze:	MEDLINE
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