Weight retention and glucose intolerance in early postpartum after gestational diabetes.

Autor:	Minschart C; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium., Myngheer N; Department of Endocrinology, General Hospital Groeninge, 8500 Kortrijk, Belgium., Maes T; Department of Endocrinology, Imelda Hospital, 2820 Bonheiden, Belgium., De Block C; Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, 2650 Edegem, Belgium., Van Pottelbergh I; Department of Endocrinology, OLV Hospital Aalst, 9300 Aalst, Belgium., Abrams P; Department of Endocrinology, GZA Hospital Sint-Vincentius, 2018 Antwerp, Belgium.; Department of Endocrinology, GZA Hospital Sint-Augustinus, 2610 Wilrijk, Belgium., Vinck W; Department of Endocrinology, GZA Hospital Sint-Augustinus, 2610 Wilrijk, Belgium., Leuridan L; Department of Endocrinology, General Hospital Klina, 2930 Brasschaat, Belgium., Driessens S; Department of Endocrinology, General Hospital Klina, 2930 Brasschaat, Belgium., Mathieu C; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.; Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium., Billen J; Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium., Matthys C; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.; Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium., Laenen A; Centre of Biostatics and Statistical Bioinformatics, KU Leuven, 3000 Leuven, Belgium., Bogaerts A; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.; Faculty of Medicine and Health Sciences, Centre for Research and Innovation in Care (CRIC), University of Antwerp, 2610 Wilrijk, Belgium., Benhalima K; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.; Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2023 May 19. Date of Electronic Publication: 2023 May 19.
DOI:	10.1093/ejendo/lvad053
Abstrakt:	Objectives: To determine risk factors for early postpartum weight retention (PPWR) and glucose intolerance (GI) in women with gestational diabetes (GDM). Design & Methods: Prospective, multicenter (n=8) cohort study in 1201 women with a recent history of GDM. Pregnancy and postpartum characteristics, and data from self-administered questionnaires were collected at the 6-16 weeks postpartum 75g OGTT. Results: Of all participants, 38.6% (463) had moderate (>0 and ≤5 kg) and 15.6% (187) had high (>5kg) PPWR. Independent predictors for early PPWR were excessive gestational weight gain (GWG), lack of breastfeeding, higher dietary fat intake, insulin use during pregnancy, multiparity, lower prepregnancy BMI, and lower education degree. Compared to PPWR <5 kg, women with high PPWR had a more impaired postpartum metabolic profile, breastfed less often, had higher depression rates [23.1% (43) vs. 16.0% (74), p=0.035] and anxiety levels, and lower quality of life. Of all participants, 28.0% (336) had GI [26.1% (313) prediabetes and 1.9% (23) diabetes]. Women with high PPWR had more often GI compared to women without PPWR [33.7% (63) vs. 24.9% (137), p=0.020]. Only 12.9% (24) of women with high PPWR perceived themselves at high risk for diabetes but they were more often willing to change their lifestyle than women with moderate PPWR. Conclusions: Modifiable risk factors such as lifestyle, prepregnancy BMI, GWG, and mental health can be used to identify a subgroup of women with GDM at the highest risk of developing early PPWR, allowing for a more personalized follow-up. (© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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