Pre-Heart Failure Longitudinal Change in a Hispanic/Latino Population-Based Study: Insights From the Echocardiographic Study of Latinos.

Autor:	Kuno T; Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: tkuno@montefiore.org., Vasquez N; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., April-Sanders AK; Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Biostatistics & Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA., Swett K; Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA., Kizer JR; Cardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA; Department of Medicine, University of California San Francisco, San Francisco, California, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA., Thyagarajan B; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Talavera GA; Department of Psychology, College of Sciences, San Diego State University, San Diego, California, USA., Ponce SG; Department of Family Medicine and Public Health, University of California San Diego, San Diego, California, USA., Shook-Sa BE; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Penedo FJ; Department of Psychology, University of Miami, Miami, Florida, USA., Daviglus ML; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA., Kansal MM; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA., Cai J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kitzman D; Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA., Rodriguez CJ; Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Jazyk:	angličtina
Zdroj:	JACC. Heart failure [JACC Heart Fail] 2023 Aug; Vol. 11 (8 Pt 1), pp. 946-957. Date of Electronic Publication: 2023 May 17.
DOI:	10.1016/j.jchf.2023.04.008
Abstrakt:	Background: Pre-heart failure (pre-HF) is an entity known to progress to symptomatic heart failure (HF). Objectives: This study aimed to characterize pre-HF prevalence and incidence among Hispanics/Latinos. Methods: The Echo-SOL (Echocardiographic Study of Latinos) assessed cardiac parameters on 1,643 Hispanics/Latinos at baseline and 4.3 years later. Prevalent pre-HF was defined as the presence of any abnormal cardiac parameter (left ventricular [LV] ejection fraction <50%; absolute global longitudinal strain <15%; grade 1 or more diastolic dysfunction; LV mass index >115 g/m 2 for men, >95 g/m 2 for women; or relative wall thickness >0.42). Incident pre-HF was defined among those without pre-HF at baseline. Sampling weights and survey statistics were used. Results: Among this study population (mean age: 56.4 years; 56% female), HF risk factors, including prevalence of hypertension and diabetes, worsened during follow-up. Significant worsening of all cardiac parameters (except LV ejection fraction) was evidenced from baseline to follow-up (all P < 0.01). Overall, the prevalence of pre-HF was 66.7% at baseline and the incidence of pre-HF during follow-up was 66.3%. Prevalent and incident pre-HF were seen more with increasing baseline HF risk factor burden as well as with older age. In addition, increasing the number of HF risk factors increased the risk of prevalence of pre-HF and incidence of pre-HF (adjusted OR: 1.36 [95% CI: 1.16-1.58], and adjusted OR: 1.29 [95% CI: 1.00-1.68], respectively). Prevalent pre-HF was associated with incident clinical HF (HR: 10.9 [95% CI: 2.1-56.3]). Conclusions: Hispanics/Latinos exhibited significant worsening of pre-HF characteristics over time. Prevalence and incidence of pre-HF are high and are associated with increasing HF risk factor burden and with incidence of cardiac events. Competing Interests: Funding Support and Author Disclosures The baseline examination of HCHS/SOL was conducted as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC652237). The following institutes/centers/offices contributed to the HCHS/SOL first funding period through a transfer of funds to the National Heart, Lung, and Blood Institute: National Institute of Deafness and Other Communications Disorders; the National Institute of Dental and Craniofacial Research; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Institute of Neurological Disorders and Stroke; and the National Institutes of Health Office of Dietary Supplements. Echo-SOL was supported by grants from the National Heart, Lung, and Blood Institute (R01 HL04199, Epidemiological Determinants of Cardiac Structure and Function among Hispanics; 2R01HL104199, Epidemiologic Determinants of Change in Cardiac Structure and Function among Hispanics: Carlos J. Rodriguez, MD, MPH, principal investigator). Dr Kizer owns stocks in Abbott, Bristol Myers Squibb, Johnson and Johnson, Medtronic, Merck, and Pfizer. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu