Neuroimaging to enhance understanding of cardiovascular autonomic changes associated with mild traumatic brain injury: a scoping review.

Autor:	Thorne J; School of Allied Health, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia., Hellewell S; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.; Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia., Cowen G; Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia., Fitzgerald M; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.; Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Jazyk:	angličtina
Zdroj:	Brain injury [Brain Inj] 2023 Aug 24; Vol. 37 (10), pp. 1187-1204. Date of Electronic Publication: 2023 May 18.
DOI:	10.1080/02699052.2023.2211352
Abstrakt:	Background: Cardiovascular changes, such as altered heart rate and blood pressure, have been identified in some individuals following mild traumatic brain injury (mTBI) and may be related to disturbances of the autonomic nervous system and cerebral blood flow. Methods: We conducted a scoping review according to PRISMA-ScR guidelines across six databases (Medline, CINAHL, Web of Science, PsychInfo, SportDiscus and Google Scholar) to explore literature examining both cardiovascular parameters and neuroimaging modalities following mTBI, with the aim of better understanding the pathophysiological basis of cardiovascular autonomic changes associated with mTBI. Results: Twenty-nine studies were included and two main research approaches emerged from data synthesis. Firstly, more than half the studies used transcranial Doppler ultrasound and found evidence of cerebral blood flow impairments that persisted beyond symptom resolution. Secondly, studies utilizing advanced MRI identified microstructural injury within brain regions responsible for cardiac autonomic function, providing preliminary evidence that cardiovascular autonomic changes are a consequence of injury to these areas. Conclusion: Neuroimaging modalities hold considerable potential to aid understanding of the complex relationship between cardiovascular changes and brain pathophysiology associated with mTBI. However, it is difficult to draw definitive conclusions from the available data due to variability in study methodology and terminology.
Databáze:	MEDLINE
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