Profile of the intestinal microbiota of patients with cystic fibrosis: A systematic review.

Autor: de Souza Furtado J; Department of Nutrition, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil., de Almeida Brasiel PG; Department of Nutrition, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil., Luquetti SCPD; Department of Nutrition, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. Electronic address: scpotentedutra@yahoo.com.br.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2023 Jun; Vol. 55, pp. 400-406. Date of Electronic Publication: 2023 Apr 15.
DOI: 10.1016/j.clnesp.2023.04.008
Abstrakt: Background & Aims: Cystic fibrosis (CF) is a multisystem disease that can compromise several human body organs. The autosomal recessive genetic disorder is caused by different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, responsible for chloride ion transport across apical membranes of epithelial cells in tissues and bicarbonate secretion. In this study, we provide a systematic review of the profile of the intestinal microbiota of cystic fibrosis individuals.
Methods: The review was conducted according to Preferred Items of Reports for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed/MEDLINE and Scopus databases were searched for relevant articles until Jully 2022.
Results: Eighteen studies (1304 participants) met the inclusion criteria. The quality and bias was assessed using the Methodological index for non-randomized studies (MINORS) tool, with the majority of the studies indicating medium to high quality. Results showed significant changes in the composition of the intestinal microbiota of the individuals with CF compared with healthy controls, with increased of Enterococcus, Veillonella, and Streptococcus, and decreased of Bifidobacterium, Roseburia, and Alistipes genus. The intestinal bacterial community of CF patients was marked by a reduction in its richness and diversity.
Conclusion: The systematic review suggests a change in the intestinal microbiota of CF individuals, characterized by a reduction in microbial diversity and abundance of some bacterial markers.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: