Black skin color but not VDR gene represent a risk factor for low serum levels of vitamin D in self-declared black individuals.

Autor: Retamoso VR; Postgraduate Program in Biochemistry, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 - Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil. Electronic address: vaneretamoso@gmail.com., Feijóo LB; Postgraduate Program in Biochemistry, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 - Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil. Electronic address: lyanaberro78@hotmail.com., Vasquez Rubio DA; Pharmacy Course, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil. Electronic address: debora.v.rubio@gmail.com., Dos Santos LAFV; Physiotherapy Course, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 - Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil. Electronic address: laurenfsantos16@gmail.com., Vargas Barcelos AL; Nutrition Course Federal University of Pampa, Campus Itaqui -RS, Brazil. Electronic address: analeticia@unipampa.edu.br., Piccoli JDCE; Postgraduate Program in Biochemistry, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 - Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil; Pharmacy Course, Federal University of Pampa - Campus Uruguaiana, BR 472 - Km 592 Mailbox 118, CEP: 97508-000, Uruguaiana - RS, Brazil. Electronic address: jacquelinepiccoli@unipampa.edu.br.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2023 Jun; Vol. 55, pp. 230-237. Date of Electronic Publication: 2023 Mar 28.
DOI: 10.1016/j.clnesp.2023.03.016
Abstrakt: Background: The absorption of vitamin D occurs via two main pathways: first, through the biosynthesis in the skin under the exposure of UV from sunlight; and second, through the intake of certain foods. However, its levels can be influenced by both genetic and environmental factors, which can generate changes such as vitamin D deficiency (hypovitaminosis D), a condition that black adults have a high potential to suffer from.
Objective: The aim of this work is to study the association of skin color (self-reported: black, brown and white), food consumption, and the BsmI polymorphism in the vitamin D receptor gene (VDR) on serum levels of vitamin D in a group of adults.
Methods: This was a cross-sectional analytical study. Individuals in the community were invited to participate in the research and, After signing the informed consent, a structured questionnaire was applied containing identification data, self-declaration of race/color, and nutritional data (Food frequency questionnaire (FFQ) and 24 h); afterwards, blood was collected for biochemical analysis, vitamin D was measured by Chemiluminescence and RT-PCR was used to evaluate the BsmI polymorphism of the VDR gene. Data was analyzed using a statistical program (SPSS 20.0) and differences between groups using p < 0.05.
Results: A total of 114 persons was evaluated between black, brown and white individuals. It was found that a large part of the sample presents hypovitaminosis D, and blacks stand out with an average serum vitamin D level of 15.9 ng/dL. The group demonstrated that dietary intake of vitamin D is low, with the present study is a pioneer in associating the polymorphism of the VDR gene (BsmI) with the consumption of foods that are considered to have a higher content of vitamin D in their composition.
Conclusion: The VDR gene does not represent a risk factor for the consumption of vitamin D in this sample, and it was found that the self-declaration of "black" skin color was an independent risk factor for low serum levels of vitamin D.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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