Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions.

Autor: Natale G; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Forte S; Genomics and Experimental Oncology Unit, IOM Ricerca, Viagrande, Italy., Messina G; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Leonardi B; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Mirra R; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Leone F; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Di Filippo V; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Pica DG; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Capasso F; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Bove M; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Noro A; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Opromolla G; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Martone M; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., De Angelis S; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy., Fiorelli A; Department of Translation Medicine, Thoracic Surgery Unit, Università della Campania 'Luigi Vanvitelli', Naples, Italy.
Jazyk: angličtina
Zdroj: Thoracic cancer [Thorac Cancer] 2023 Jul; Vol. 14 (19), pp. 1824-1830. Date of Electronic Publication: 2023 May 18.
DOI: 10.1111/1759-7714.14927
Abstrakt: Background: Intrathoracic neurogenic tumors (INTs) are derived from nerve tissue and grow within the chest. Preoperative diagnosis can be challenging and only complete surgical exeresis enables confirmation of the suspected diagnosis. Here, we analyzed our experience on management of paravertebral lesions with solid and cystic patterns.
Methods: A monocentric retrospective study was conducted, which included 25 consecutive cases of ITNs in the period from 2010 to 2022. These cases had been surgically treated by thoracoscopic resection alone, or in combination with neurosurgery in the case of dumbbell tumors. The demographic and operative data along with complications were recorded and analyzed.
Results: Twenty-five patients were diagnosed with a paravertebral lesion of which 19 (76%) had solid features and six (24%) had cystic features. The most common diagnosis was schwannoma (72%), followed by neurofibroma (20%) and malignant schwannoma (8%). In four cases (12%) the tumor showed an intraspinal extension. None of the patients had recurrence until 6 months of follow-up. Comparison between the VATS and thoracotomy procedures showed that outcome of discharge on the postoperative day, on average, was 2.61 ± 0.5 versus 3.51 ± 0.53, respectively (p-value <0.001).
Conclusion: The treatment of choice for INTs is complete resection which is tailored to tumor size, location, and extension. In our study, paravertebral tumors with cystic characteristics were not associated with an intraspinal extension and did not show a different behavior from solid tumors.
(© 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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