End-of-season influenza vaccine effectiveness during the Southern Hemisphere 2022 influenza season - Chile, Paraguay, and Uruguay.

Autor:	Chard AN; Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, USA. Electronic address: mmn9@cdc.gov., Nogareda F; Pan American Health Organization, Washington DC, USA. Electronic address: nogaredfra@paho.org., Regan AK; Pan American Health Organization, Washington DC, USA; School of Nursing and Health Professions, University of San Francisco, San Francisco, USA; Fielding School of Public Health, University of California Los Angeles, Los Angeles, USA., Barraza MFO; Ministry of Health, Santiago, Chile., Fasce RA; Virology Department, Public Health Institute of Chile, Santiago, Chile., Vergara N; Ministry of Health, Santiago, Chile., Avendaño M; Ministry of Health, Santiago, Chile., Penayo E; Ministry of Public Health and Social Welfare, Asunción, Paraguay., Vázquez C; Ministry of Public Health and Social Welfare, Asunción, Paraguay., Von Horoch M; Ministry of Public Health and Social Welfare, Asunción, Paraguay., Michel F; Pan American Health Organization, Asunción, Paraguay., Alfonso A; Ministry of Public Health, Montevideo, Uruguay., Mogdasy C; Ministry of Public Health, Montevideo, Uruguay., Chiparelli H; Ministry of Public Health, Montevideo, Uruguay., Goñi N; Ministry of Public Health, Montevideo, Uruguay., Alegretti M; Ministry of Public Health, Montevideo, Uruguay., Loayza S; Pan American Health Organization, Washington DC, USA., Couto P; Pan American Health Organization, Washington DC, USA., Rodriguez A; Pan American Health Organization, Washington DC, USA., Salas D; Pan American Health Organization, Washington DC, USA., Fowlkes AL; Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, USA., Azziz-Baumgartner E; Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, USA.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2023 Sep; Vol. 134, pp. 39-44. Date of Electronic Publication: 2023 May 16.
DOI:	10.1016/j.ijid.2023.05.015
Abstrakt:	Objectives: This study estimated the 2022 end-of-season influenza vaccine effectiveness (VE) against severe acute respiratory illness (SARI) hospitalization in Chile, Paraguay, and Uruguay. Methods: We pooled surveillance data from SARI cases in 18 sentinel surveillance hospitals in Chile (n = 9), Paraguay (n = 2), and Uruguay (n = 7) from March 16-November 30, 2022. VE was estimated using a test-negative design and logistic regression models adjusted for country, age, sex, presence of ≥1 comorbidity, and week of illness onset. VE estimates were stratified by influenza virus type and subtype (when available) and influenza vaccine target population, categorized as children, individuals with comorbidities, and older adults, defined per countries' national immunization policies. Results: Among the 3147 SARI cases, there were 382 (12.1%) influenza test-positive case patients; 328 (85.9%) influenza case patients were in Chile, 33 (8.6%) were in Paraguay, and 21 (5.5%) were in Uruguay. In all countries, the predominant subtype was influenza A(H3N2) (92.6% of influenza cases). Adjusted VE against any influenza-associated SARI hospitalization was 33.8% (95% confidence interval: 15.3%, 48.2%); VE against influenza A(H3N2)-associated SARI hospitalization was 30.4% (95% confidence interval: 10.1%, 46.0%). VE estimates were similar across target populations. Conclusion: During the 2022 influenza season, influenza vaccination reduced the odds of hospitalization among those vaccinated by one-third. Health officials should encourage influenza vaccination in accordance with national recommendations. Competing Interests: Declarations of Competing Interest The authors have no competing interests to declare. (Copyright © 2023. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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