Exosomal non-coding RNAs' role in immune regulation and potential therapeutic applications.

Autor: J Saadh M; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan; Applied Science Research Center. Applied Science Private University, Amman, Jordan., Abedi Kiasari B; Virology Department, Faculty of Veterinary Medicine, The University of Tehran, Tehran, Iran., Shahrtash SA; Department of Pharmaceutical Engineering, Alborz Campus, University of Tehran, Tehran, Iran., Arias-Gonzáles JL; Department of Social Sciences, Faculty of Social Studies, Pontifical University of Peru, Peru., Chaitanya M; Department of Pharmacognosy, School of Pharmacy, Lovely professional university Phagwara, Punjab 144001, India., Cotrina-Aliaga JC; Faculty of Human Medicine, Universidad Privada San Juan Bautista, Chincha, Peru., Kadham MJ; College of Medical Techniques, Al-Farahidi University, Baghdad, Iraq., Sârbu I; 2nd Department of Surgery - Pediatric Surgery and Orthopedics, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania. Electronic address: sarbu.ioan@umfiasi.ro., Akhavan-Sigari R; Department of Neurosurgery, University Medical Center Tuebingen, Germany; Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 Jul; Vol. 247, pp. 154522. Date of Electronic Publication: 2023 May 08.
DOI: 10.1016/j.prp.2023.154522
Abstrakt: Exosomes are now significant players in both healthy and unhealthy cell-to-cell communication. Exosomes can mediate immune activation or immunosuppression, which can influence the growth of tumors. Exosomes affect the immune responses to malignancies in various ways by interacting with tumor cells and the environment around them. Exosomes made by immune cells can control the growth, metastasis, and even chemosensitivity of tumor cells. In contrast, exosomes produced by cancer cells can encourage immune responses that support the tumor. Exosomes carry circular RNAs, long non-coding RNAs, and microRNAs (miRNAs), all involved in cell-to-cell communication. In this review, we focus on the most recent findings concerning the role of exosomal miRNAs, lncRNAs, and circRNAs in immune modulation and the potential therapeutic implications of these discoveries.
Competing Interests: Declaration of Competing Interest The authors declare they have no conflict of interest.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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