Bone Mineral Loss at the Distal Femur and Proximal Tibia Following Spinal Cord Injury in Men and Women.

Autor:	Mazur CM; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Edwards WB; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Haider IT; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Fang Y; Department of Physical Therapy, Rosalind Franklin University, North Chicago, IL, United States., Morse LR; Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, United States., Schnitzer TJ; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Simonian N; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Troy KL; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA United States. Electronic address: ktroy@wpi.edu.
Jazyk:	angličtina
Zdroj:	Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2023 Jul-Sep; Vol. 26 (3), pp. 101380. Date of Electronic Publication: 2023 May 05.
DOI:	10.1016/j.jocd.2023.101380
Abstrakt:	Purpose: Spinal cord injury (SCI) causes rapid bone loss and increases risk of fragility fractures in the lower extremities. The majority of individuals with SCI are men, and few studies have investigated sex as a biological variable in SCI-induced osteoporosis. This cross-sectional study aimed to quantify sex-specific differences in bone mineral following SCI. Methods: Quantitative computed tomography (QCT) scans of the distal femur and proximal tibia were obtained at baseline of one of four clinical trials enrolling people who sustained SCI 1 month to 50 years prior to recruitment. Bone volume (BV), bone mineral content (BMC), bone mineral density (BMD), and bending strength index (BSI) were quantified in the integral, trabecular, and cortical bone in the epiphysis, metaphysis and diaphysis. Scans from 106 men and 31 women were analyzed to measure sex-specific effects on bone loss over time post-SCI. Results: BMC and BSI declined exponentially as a function of time post-SCI and were best described by separate decay curves for men and women. Women had BV, BMC, and BSI at 58-77% that of men in the acute and plateau phases, with both sexes showing similar rates of loss as a function of time post-SCI. Trabecular BMD was best described as an exponential decay versus time post-SCI, with no sex-specific differences. Conclusions: Due to consistently lower BV, BMC, and BSI, women may be more susceptible to fractures after SCI than men. Competing Interests: Declaration of Competing Interest Courtney M. Mazur, W. Brent Edwards, Ifaz T. Haider, Ying Fang, Leslie R. Morse, Thomas J. Schnitzer, Narina Simonian, and Karen L. Troy each declare that they have no conflict of interest. (Copyright © 2023 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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