| Autor: |
Lam SH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan., Liu HK; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.; Ph.D. Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan., Chung SY; Department of Marine Biotechnology and Resource, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan., Chang JL; Department of Science Application and Dissemination, National Taichung University of Education, Taichung 403, Taiwan., Hong MX; Department of Marine Biotechnology and Resource, National Sun Yat-sen University, Kaohsiung 80424, Taiwan., Kuo SC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan., Liaw CC; Department of Marine Biotechnology and Resource, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 11031, Taiwan. |
| Abstrakt: |
Seven previously undescribed diterpenoids, tinocrisposides A-D ( 1 - 4 ) and borapetic acids A ( 5 ), B ( 6 ), and C ( 7 ), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12 , 14 - 16 , and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells. |
