| Autor: |
Blejewski RC; Department of Psychology, University of North Carolina Wilmington., Van Heukelom JT; Department of Psychology, University of North Carolina Wilmington., Langford JS; Department of Psychology, University of North Carolina Wilmington., Hunt KH; Department of Psychology, University of North Carolina Wilmington., Rinkert IR; Department of Psychology, University of North Carolina Wilmington., Wagner TJ; Department of Psychology, University of North Carolina Wilmington., Pitts RC; Department of Psychology, University of North Carolina Wilmington., Hughes CE; Department of Psychology, University of North Carolina Wilmington. |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and clinical psychopharmacology [Exp Clin Psychopharmacol] 2023 Dec; Vol. 31 (6), pp. 1050-1068. Date of Electronic Publication: 2023 May 18. |
| DOI: |
10.1037/pha0000646 |
| Abstrakt: |
μ-Opioid agonists (e.g., morphine) typically increase impulsive choice, which has been interpreted as an opioid-induced increase in sensitivity to reinforcement delay. Relatively little research has been done with opioids other than morphine (e.g., oxycodone), or on sex differences in opioid effects, on impulsive choice. The present study investigated the effects of acute (0.1-1.0 mg/kg) and chronic (1.0 mg/kg twice/day) administration of oxycodone on choice controlled by reinforcement delay, a primary mechanism implicated in impulsive choice, in female and male rats. Rats responded under a concurrent-chains procedure designed to quantify the effects of reinforcement delay on choice within each session. For both sexes, choice was sensitive to delay under this procedure. Sensitivity to delay under baseline was slightly higher for males than females, suggesting more impulsive choice with males. When given acutely, intermediate and higher doses of oxycodone decreased sensitivity to delay; this effect was larger and more reliable in males than females. When given chronically, sex differences were also observed: tolerance developed to the sensitivity-decreasing effects in females, whereas sensitization developed in males. These data suggest that reinforcement delay may play an important role in sex differences in impulsive choice, as well as in the effects of acute and chronic administration of opioids in impulsive choice. However, drug-induced changes in impulsive choice could be related to at least two potential behavioral mechanisms: reinforcement delay and/or reinforcement magnitude. Effects of oxycodone on sensitivity to reinforcement magnitude remain to be fully characterized. (PsycInfo Database Record (c) 2023 APA, all rights reserved). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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