Vitamin D insufficiency and serum levels related to the incidence and stage of cutaneous melanoma: a systematic review and meta-analysis.

Autor:	Shellenberger RA; Department of Internal Medicine, Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan., Gowda S; Department of Internal Medicine, Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan., Kurn H; Department of Internal Medicine, Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan., Albright J; Methods Consultants of Ann Arbor, Ypsilanti, Michigan, USA., Mayo MH; Department of Internal Medicine, Trinity Health Ann Arbor Hospital, Ann Arbor, Michigan.
Jazyk:	angličtina
Zdroj:	Melanoma research [Melanoma Res] 2023 Aug 01; Vol. 33 (4), pp. 265-274. Date of Electronic Publication: 2023 May 18.
DOI:	10.1097/CMR.0000000000000897
Abstrakt:	Cutaneous melanoma (CM) is the deadliest skin cancer, and vitamin D insufficiency has been suggested as a risk factor. We evaluated the relationship between both vitamin D insufficiency and 25-hydroxy vitamin D levels with the incidence and stage of CM. Five databases were searched from inception until 11 July 2022. Inclusion criteria were cohort and case-control studies that reported mean 25-hydroxy vitamin D levels or the presence of vitamin D insufficiency in CM patients and compared with healthy controls; or those that reported vitamin D insufficiency and Breslow tumor depth or the development of metastasis in CM. Fourteen studies were included in the analysis. Statistically significant relationships were found between vitamin D level <20 ng/dl and incidence of CM [pooled RR 1.45, 95% confidence interval (CI) 1.04-2.02]; lower mean vitamin D level and Breslow depth >1 mm (SMD 0.19, 95% CI 0.11-0.28); and vitamin D level >20 ng/dl and Breslow depth <1 mm (pooled RR 0.69, 95% CI 0.58-0.82). Statistical significance was not found in the relationships between vitamin D levels and the presence of metastasis (pooled SMD -0.13, 95% CI, -0.38 to 0.12); or mean vitamin D level and the incidence of CM (pooled SMD -0.39, 95% CI, -0.80 to 0.01). We identified an association of increased incidence of CM and vitamin D insufficiency, as well as less favorable Breslow tumor depth with lower levels of vitamin D and the presence of vitamin D insufficiency. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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