Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam.

Autor:	Ngoc Tram HT; Department of Obstetrics and Gynecology, Hanoi Medical University, Hanoi, Vietnam.; Department of Obstetrics and Gynecology, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam., Thu Huong BT; Department of Biochemistry, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam.; Department of Immunology and Molecular Genetics, Thai Nguyen National Hospital, Thai Nguyen, Vietnam., Duc Hinh N; Department of Obstetrics and Gynecology, Hanoi Medical University, Hanoi, Vietnam., Thuy PT; Department of Biochemistry, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam., Lan Anh LT; Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam., Kim Phuon DT; Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam., Thu Lan H; Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam., Cam Tu H; Center of Gene and Protein Research, Hanoi Medical University, Hanoi, Vietnam.; Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany., Koerber N; Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research (DZIF), Munich and Hamburg Partner sites, Germany., Bauer T; Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research (DZIF), Munich and Hamburg Partner sites, Germany., Khanh Lam H; Department of Telecomunication, Hung Yen University of Technology and Education, Hung Yen, Vietnam., Manh Ha N; Department of Histology and Embryology, Hanoi Medical University, Hanoi, Vietnam., Minh Duc N; Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Thanh Hiep N; Department of Family Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Protzer U; Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research (DZIF), Munich and Hamburg Partner sites, Germany., Tien Dung N; Department of Internal Medicine, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam.
Jazyk:	angličtina
Zdroj:	La Clinica terapeutica [Clin Ter] 2023 May-Jun; Vol. 174 (3), pp. 266-274.
DOI:	10.7417/CT.2023.2533
Abstrakt:	Background: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We investigate of the correlation between peripheral blood cell levels, HBV DNA, and the risk of transmission to the baby in pregnant women infected with hepatitis B. Methods: A multidimensional analysis was performed on data collected from 60 Vietnamese pregnant women and their babies (cord blood). Results: Taking the risk ratio test results of cord blood HBsAg as a positive probability, the boundary of maternal PBMC concentration is 8.03x106 cells/ml (with negative correlation) and for CBMCs is 6.64x106 cells/ml (with positive correlation). That means that HBsAg positivity in the blood may be related to the increasing of CBMCs and the diminution of maternal PBMCs. When the maternal viral load is higher than 5x107 copies/ml, the risk of being HBsAg-positive in cord blood is 123% (RR=2.23 [1.48,3.36]); when the viral load is lower than this baseline, the risk is decreased by 55% (RR=0.45 [0.30,0.67]) (p<0.001). Conclusions: With several steps of the analysis, this study found maternal peripheral blood cell levels and cord blood positively cor-related in pregnant women with a load lower than 5x107 copies of HBV DNA/ml. The study's results suggest that the role of PBMCs and HBV DNA in vertical infection is essential.
Databáze:	MEDLINE
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